Immunogenetics

, Volume 13, Issue 3, pp 237–245 | Cite as

Regulation of the production of murine IgG2a by an H-2-linked gene and other unlinked genes

  • Andrew P. Dowsett
  • Leonore A. Herzenberg
  • Leonard A. Herzenberg
Original Investigations
Received:

Abstract

Alleles of at least two loci (rig-1 and Rig-2) regulate the levels of serum immunoglobulin of the Igh-1b class and allotype in BALB/c Igb (BAB/14) and (BALB/c × BAB/14)F1 mice. The combined effect of the BALB/c alleles at these two loci is to lower Igh-1b levels significantly below those observed in other strains and below their own levels of Igh-1a in allotype heterozygous mice. The rig-1 locus is closely linked to or within the H-2 complex. Two alleles have been defined: rig-1d and rig-1b in H-2d and H-2b haplotypes, respectively. Homozygous rig-1d d animals heterozygous for the BALB/c Rig-2 allele(s) have very low levels of Igh-1b. The designation of Rig-2 is provisional since it has not been mapped or defined as a single locus.

Keywords

Combine Effect Single Locus Serum Immunoglobulin Heterozygous Mouse Unlinked Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Andrew P. Dowsett
    • 1
  • Leonore A. Herzenberg
    • 1
  • Leonard A. Herzenberg
    • 1
  1. 1.Department of GeneticsStanford University School of MedicineStanford

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