Skeletal Radiology

, Volume 11, Issue 2, pp 96–101 | Cite as

Chondrosarcoma in children subsequent to other malignant tumours in different locations

  • D. Vanel
  • C. Coffre
  • L. Zemoura
  • O. Oberlin


During recent years the combination of surgery, radiotherapy, and multiple chemotherapy in the treatment of patients with cancer has resulted in increased survival periods and, in some cases, complete cures. In children, however, the subsequent development of other and apparently unrelated malignancies has been observed 20 times more commonly than in a control group. This paper reports the occurrence of chondrosarcoma of the femur in two children who had been treated successfully for malignant tumours of soft tissue. One of these tumours was a malignant fibrous histiocytoma in the muscles of the forearm; the other was a rhabdomyosarcoma of the cheek. The intervals between termination of treatment of these lesions and recognition of the chondrosarcoma were five years and 10 years, respectively. In addition to surgical and radiotherapeutic measures, both children had received high doses of chemotherapy.

Key words

Second malignant tumours Malignant fibrous histiocytoma Rhabdomyosarcoma Chondrosarcoma Chemotherapy 


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  1. 1.
    Cahan WG, Woodward HQ, Higinbotham NL (1948) Sarcoma arising in irradiated bone. Cancer 1:3Google Scholar
  2. 2.
    Harris CC (1976) The carcinogenicity of anticancer drugs: A hazard in man. Cancer 37:1014Google Scholar
  3. 3.
    Ho Kim J, Chu FC, Woodward HQ, Melamed MR, Huvos A, Cantin J (1978) Radiation-induced soft tissue and bone sarcoma. Radiology 129:501Google Scholar
  4. 4.
    Kenney PJ, Gilula LA, Murphy WA (1981) The use of computed tomography to distinguish osteochondroma and chondrosarcoma. Radiology 139:129Google Scholar
  5. 5.
    Li FP (1977) Second malignant tumors after cancer in childhood. Cancer 40:1899Google Scholar
  6. 6.
    Libshitz HI, Cohen MA (1982) Radiation induced osteochondromas. Radiology 142:643Google Scholar
  7. 7.
    Lukens JA, McLeod R, Sim F (1982) Computed tomographic evaluation of primary osseous malignant neoplasms. AJR 139:45Google Scholar
  8. 8.
    Meadows AT, D'Angio GJ, Mike V, Banfi A, Harris C, Jenkin RDT, Schwartz A (1977) Patterns of second malignant neoplasms in children. Cancer 40:1903Google Scholar
  9. 9.
    Meadows AT, Strong LC, Li FP, D'Angio GJ, Schweisguth O, Freeman AI, Jenkin RDT, Morris Jones OP, Nesbit ME (1980) Bone sarcoma as a second malignant neoplasms in children. Influence of radiation and genetic predisposition. Cancer 46:2603Google Scholar
  10. 10.
    Oberlin O, Flamant F, Bernard A (1984) Les secondes tumeurs malignes de l'enfant. Etude de 38 cas observés à l'Institut Gustave-Roussy. Arch Fr Pédiatr (in press)Google Scholar
  11. 11.
    Penn I (1976) Second malignant neoplasms associated with immunosuppressive medications. Cancer 37:1024Google Scholar
  12. 12.
    Regelson W, Bross IDJ, Hananian J, Nigogusyan G (1965) Incidence of second primary tumors in children with cancer and leukemia. A seven year survey of 150 consecutive autopsied cases. Cancer 18:58Google Scholar
  13. 13.
    Steiner GC (1965) Postirradation sarcoma of bone. Cancer 18:603Google Scholar
  14. 14.
    Tountas AA, Fornasier VL, Harwood AR, Leung PM (1979) Postirradiation sarcoma of bone. A perspective. Cancer 43:182Google Scholar

Copyright information

© International Skeletal Society 1984

Authors and Affiliations

  • D. Vanel
    • 1
  • C. Coffre
    • 1
  • L. Zemoura
    • 2
  • O. Oberlin
    • 3
  1. 1.Department of RadiologyInstitut Gustave-RoussyParisFrance
  2. 2.Department of HistopathologyInstitut Gustave-RoussyParisFrance
  3. 3.Department of Paediatric OncologyInstitut Gustave-RoussyParisFrance

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