Archiv für Psychiatrie und Nervenkrankheiten

, Volume 232, Issue 4, pp 299–304 | Cite as

Increased serum glutamate in depressed patients

  • J. S. Kim
  • W. Schmid-Burgk
  • D. Claus
  • H. H. Kornhuber
Article

Summary

Glutamate concentration was determined in serum from endogenous and neurotic depressive patients, in persons with schizophrenia or schizoaffective disorder, and in normal subjects.

The mean serum glutamate level in the endogenous and neurotic depressive patients was found to be significantly higher than in any of the other groups. No other statistically significant differences were found. Statistical analysis revealed that the elevated serum glutamate concentration in the endogenous and neurotic depressive patients was probably caused by medication. These results are discussed in view of the effect of antidepressants upon the serum glutamate in the affective disorders.

Key words

Serum glutamate Endogenous depression Neurotic depression Antidepressants 

Zusammenfassung

Der Serum-Glutamatgehalt wurde bei endogen depressiven, neurotisch depressiven, schizophrenen und schizoaffektiven Patienten sowie gesunden Kontrollpersonen bestimmt.

Hierbei zeigte sich, daß die Serumglutamatspiegel bei endogen und neurotisch Depressiven signifikant höher waren als bei den anderen Gruppen. Zwischen schizophrenen und schizoaffektiven Patienten sowie Kontrollen zeigten sich dagegen keine signifikanten Unterschiede. Die weitere Analyse der Daten erbrachte die Hypothese, daß die erhöhten Serum-Glutamat-Konzentrationen bei endogen und neurotisch Depressiven eine Folge der antidepressiven Medikation sind. Diese Ergebnisse werden im Hinblick auf die Wirkung der Antidepressiva auf das Serum-Glutamat bei affektiven Störungen diskutiert.

Schlüsselwörter

Serum-Glutamat endogene Depression neurotische Depression Antidepressiva 

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References

  1. Angst J, Woggon B, Schoepf J (1977) The treatment of depression with l-5-hydroxytryptophan versus imipramine. Results of two open and one double blind study. Arch Psychiatr Nervenkr 224:175–186Google Scholar
  2. Åsberg M, Thoren P, Täskman L (1976) “Serotonin depression”-a biochemical subgroup within the affective disorders? Science 191:478–481Google Scholar
  3. Birkmayer W, Riederer P (1975) Biochemical post-mortem findings in depressed patients. J Neural Transm 37:95–109Google Scholar
  4. Coppen A, Eccleston EG, Peet M (1972) Total and free tryptophan concentration in the plasma of depressive patients. Lancet II:1415–1416Google Scholar
  5. Coppen A, Eccleston EG, Peet M (1973) Total and free tryptophan concentration in the plasma of depressive patients. Lancet II:60–63Google Scholar
  6. d'Elia G, Hanson L, Raotma H (1978) l-tryptophan and 5-hydroxytryptophan in the treatment of depression. Acta Psychiatr Scand 57:239–252Google Scholar
  7. Graham T, Aprison MH (1966) Fluormetric determination of aspartate, glutamate and γ-aminobutyrate in nervous tissue using enzymic method. Anal Biochem 15:487–497Google Scholar
  8. Hornykiewicz O (1974) Some remarks concerning the possible role of brain monoamines (dopamine, noradrenaline, serotonin) in mental disorders. J Psychiatr Res 11:249–253Google Scholar
  9. Mendels J, Frazer A, Fitzgerald RG, Ramsey A, Stokes JW (1972) Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients. Science 175:1380–1382Google Scholar
  10. Moller SE, Kirk L, Fremming KH (1976) Plasma amino acid as an index for subgroups in manic depressive psychosis: correlation to effect of tryptophan. Psychopharmacol 49:205–213Google Scholar
  11. Moller SE, Kirk L, Honore P (1980) Relationship between plasma ratio of tryptophan to competing amino acids and the response to 1-tryptophan treatment in endogenously decreased patients. J Affect Dis 2:47–59Google Scholar
  12. Munro HN (1979) Factors in the regulation of glutamate metabolism. In: Filer JLJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds) Adv Biochem Physiol. Raven Press, New York, pp 55–68Google Scholar
  13. Pardridge WM (1977) Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J Neurochem 28:103–108Google Scholar
  14. Van Praag HM, Korf J, Puite J (1970) 5-hydroxyindolacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. Nature 225:1259–1260Google Scholar
  15. Riley GJ, Shaw DM (1976) Total and non-bound tryptophan in unipolar illness. Lancet II:1249Google Scholar
  16. Schmid-Burgk W, Kim JS, Lischewski R, Raßmann W (1981) Levels of total and free tryptophan in the plasma of endogenous and neurotic depressives. Arch Psychiatr Nervenkr 231:35–39Google Scholar
  17. Shaw D, Campus F, Eccleston E (1967) 5-hydroxytryptamine in the hindbrain of depressive suicides, Br J Psychiatr 113:1407–1411Google Scholar
  18. Stegink LD, Reynolds WA, Filer JLJ, Baker GL, Daabees TT, Pitkin RM (1979) Comparative metabolism of glutamate in the mouse, monkey, and man. In: Filer JLJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds) Adv Biochem Physiol. Raven Press, New York, pp 85–102Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. S. Kim
    • 1
  • W. Schmid-Burgk
    • 2
  • D. Claus
    • 1
  • H. H. Kornhuber
    • 1
  1. 1.Abteilung für Neurologie der Universität UlmSchwendiBundesrepublik Deutschland
  2. 2.Psychiatrisches Landeskrankenhaus Bad SchussenriedBad SchussenriedBundesrepublik Deutschland

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