, Volume 25, Issue 3, pp 200–203 | Cite as

Mouse candidiasis

II. Host responses are T-cell dependent and regulated by genes in the major histocompatibility complex
  • R. B. Ashman


Administration of a Thy-1.2-specific monoclonal antibody to BALB/c mice resulted in a significant decrease in the efficiency of clearance of Candida albicans from the spleen. The rate of clearance of organisms from the spleen of congenic mice was determined by genes in the major histocompatibility complex, as was the magnitude of the inflammatory response in the popliteal lymph node after footpad immunization. These results formally demonstrate the involvement of T cells in host responses to primary candida infection.


Lymph Node Monoclonal Antibody Inflammatory Response Major Histocompatibility Complex Candida Albicans 
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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. B. Ashman
    • 1
  1. 1.Clinical Immunology Research UnitPrincess Margaret HospitalSubiacoWestern Australia

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