Neuroradiology

, Volume 31, Issue 5, pp 373–376

Duchenne muscular dystrophy carriers

Proton spin-lattice relaxation times of skeletal muscles on magnetic resonance imaging
  • K. Matsumura
  • I. Nakano
  • N. Fukuda
  • H. Ikehira
  • Y. Tateno
  • Y. Aoki
Originals

Summary

By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated form the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower, than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly.

Key words

Proton MRI T1 value Duchenne muscular dystrophy carrier Creatine kinase 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Matsumura
    • 1
  • I. Nakano
    • 1
  • N. Fukuda
    • 2
  • H. Ikehira
    • 2
  • Y. Tateno
    • 2
  • Y. Aoki
    • 3
  1. 1.Department of NeurologyShimoshizu National HospitalChibaJapan
  2. 2.Division of Clinical ResearchNational Institute of Radiological SciencesChibaJapan
  3. 3.Division of HospitalNational Institute of Radiological SciencesChibaJapan

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