Archiv für Psychiatrie und Nervenkrankheiten

, Volume 231, Issue 3, pp 221–225

Glutamate in schizophrenics and healthy controls

  • Wagner F. Gattaz
  • Daher Gattaz
  • Helmut Beckmann
Article

Summary

Cerebrospinal fluid (CSF) glutamate levels were measured in 28 paranoid schizophrenic patients and 15 healthy individuals. From the 28 patients 15 were treated with neuroleptic drugs and 13 did not take any drugs. No significant difference was found between glutamate in patients without neuroleptics and controls. However, CSF glutamate was significantly higher in patients taking neuroleptics than in controls (P<0.001) or in patients without neuroleptics (P<0.01).

This and other data from the literature indicate that enhanced levels of cerebral glutamate may be significant for the antipsychotic efficacy of neuroleptic drugs.

Key words

Schizophrenia CSF Glutamate Neuroleptic drugs 

Zusammenfassung

Bei 28 paranoid Schizophrenen und 15 psychisch gesunden Kontrollen wurde die Glutamatkonzentration im Liquor cerebrospinalis gemessen. Fünfzehn der 28 Patienten standen unter neuroleptischer Therapie, 13 waren völlig ohne Medikamente. Es ergab sich kein signifikanter Unterschied zwischen Patienten ohne Neuroleptika und Kontrollen. Allerdings war die Glutamatkonzentration bei Patienten, die Neuroleptika erhielten, signifikant höher als bei Patienten ohne Neuroleptika (P<0.01) oder Kontrollen (P<0.001).

Dieses Ergebnis, zusammen mit anderen Befunden aus der Literatur, läßt daran denken, daß die Steigerung der cerebralen Glutamatkonzentration nicht ohne Bedeutung für die antipsychotische Wirksamkeit der Neuroleptika sein mag.

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Wagner F. Gattaz
    • 1
  • Daher Gattaz
    • 2
  • Helmut Beckmann
    • 1
  1. 1.Psychiatrische Klinik im Zentralinstitut für Seelische GesundheitMannheim 1Federal Republic of Germany
  2. 2.Clinica Borda Do Campo Santo AndréS.P.Brazil

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