Autorhythmicity and entrainment in excitable membranes
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Abstract
Low calcium increases the excitability of neurones and can induce autorhythmicity in excitable cells. Numerical solutions of the Hodgkin-Huxley membrane equations, and numerical evaluations of the small-signal impedance and admittance are used to illustrate the increase in resonance produced by low [Ca2+]0. The resonant frequency may be located either by the peak of the amplitude of the impedance, or by the frequency at which the phase angle is zero for 1:1 entrained action potentials. Autorhythmicity is produced by any mechanism which increases the resonant peak of the amplitude of the membrane impedance.
Keywords
Calcium Resonant Frequency Phase Angle Numerical Evaluation Resonant Peak
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