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Biological Cybernetics

, Volume 50, Issue 2, pp 119–134 | Cite as

A hypothetical explanation of congenital nystagmus

  • Lance M. Optican
  • David S. Zee
Article

Abstract

Congenital nystagmus (CN) is a conjugate, rhythmic, eye movement disorder characterized by a wide variety of waveforms ranging from jerk to pendular types. No detailed mechanisms have been proposed to explain the generation of the CN wave-form This paper proposes a hypothetical mechanism for CN, and shows with computer simulations that a model based on this hypothesis can account for a variety of disparate waveforms. The basis of this model is a gaze-holding network, or neural integrator, that has both position and velocity feedback loops. The signals carried in these loops could arise from either afference or efference. In normal subjects, the position feedback would be positive and the velocity feedback would be negative. Both would help to increase the time constant of an imperfect neural integrator in the brain stem. We propose that in patients with CN the sign of the velocity pathway is reversed, making the neural integrator unstable. This instability could manifest as many different CN waveforms, depending on the direction and velocity of post-saccadic ocular drift and actions of nonlinearities within the position and velocity feedback loops. Thus a single underlying abnormality may be responsible for a variety of CN waveforms.

Keywords

Computer Simulation Time Constant Feedback Loop Brain Stem Movement Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Lance M. Optican
    • 1
  • David S. Zee
    • 2
    • 3
    • 4
  1. 1.Laboratory of Sensorimotor Research, National Eye InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Clinical Branch, Neuro-ophthalmology, National Eye InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Department of Neurology, OphthalmologyJohns Hopkins School of MedicineBaltimoreUSA
  4. 4.Department of NeuroscienceJohns Hopkins School of MedicineBaltimoreUSA

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