Human Genetics

, Volume 62, Issue 3, pp 210–213 | Cite as

Pericentric X inversion in dizygotic twins who differ in X chromosome inactivation and menstrual cycle function

  • Elisabeth A. Keitges
  • Catherine G. Palmer
  • David D. Weaver
Original Investigations
Received:
Revised:

Summary

A 21-year-old female dizygotic twin was referred for cytogenetic evaluation because of mild mental retardation. Significant history, clinical, and physical findings included irregular menses, mildly coarse facies, and microcornea. Chromosome analysis revealed a pericentric inversion of the X chromosome, 46,X,inv(X)(p11;q22). Her twin who is phenotypically normal was also found to carry the same inversion. The twins differ significantly in X chromosome inactivation and menstrual cycle function.

Keywords

Internal Medicine Metabolic Disease Menstrual Cycle Mental Retardation Chromosome Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Elisabeth A. Keitges
    • 1
  • Catherine G. Palmer
    • 1
  • David D. Weaver
    • 1
  1. 1.Department of Medical GeneticsIndiana University School of MedicineIndianapolisUSA

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