Archives of Toxicology

, Volume 56, Issue 3, pp 201–203 | Cite as

Accidental exposure to sarin: vision effects

  • Roy H. Rengstorff
Original Investigations


Two men were accidentally exposed to vapors of sarin, a cholinesterase inhibitor and extremely toxic nerve gas. Diagnosis was confirmed by depressed cholinesterase activity, and fixed extremely miotic pupils. No other signs or symptoms developed and neither man required treatment. Recovery to normal cholinesterase activity was gradual over a 90-day period. Pupillary reflexes were not detectable until 11 days after exposure; the miotic pupils dilated slowly over a 30–45 day-period. Eye pain and blurred vision did not occur; visual acuity and amplitude of accommodation were improved for several weeks. Other functions not affected significantly were intraocular pressure, visual fields, color vision, heterophorias, and vergences.

Key words

Sarin Vision Organophosphates Cholinesterase Miosis 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Roy H. Rengstorff
    • 1
  1. 1.U.S. Army Medical Research Institute for Chemical DefenseUSA

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