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Molecular and General Genetics MGG

, Volume 195, Issue 1–2, pp 52–56 | Cite as

Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans

  • A. M. Rose
  • D. L. Baillie
  • J. Curran
Article

Summary

In this paper we describe the meiotic pairing behavior of two free duplications in Caenorhabditis elegans. sDp1 is a duplication of approximately 30 map units of the right portion of linkage group I including unc-74 to unc-54. This duplication pairs, recombines, and apparently segregates from one of the normal homologues. A second duplication, sDp2, is a duplication of approximately 15 map units of the left portion of the linkage group. sDp2 was not observed to recombine with the normal homologue but did suppress exchange between the two normal homologues in a sDp2/ ++ / dpy-5 unc-35 heterozygote. Although a number of free duplications have been described previously in Caenorhabditis elegans, none of these have been shown to pair with normal homologues. The meiotic behavior of the duplications described in this paper can be understood assuming the existence in C. elegans chromosomes of pairing sites of the type described in D. melanogaster chromosomes (I. Sandler 1956; Hawley 1980).

Keywords

Linkage Group Caenorhabditis Elegans Meiotic Behavior Left Portion Meiotic Pairing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94Google Scholar
  2. Clarke L, Carbon J (1983) Genomic substitutions of centromeres in Saccharomyces cerevisiae. Nature 287:504–509Google Scholar
  3. Grell RF (1976) Distributive pairing. In: Ashburner M, Novitski E (eds) The genetics and biology of Drosophila, vol Ia. Academic Press, New York, pp 436–486Google Scholar
  4. Hawley RS (1980) Chromosomal sites necessary for normal levels of meiotic recombination in Drosophila melanogaster: I. Evidence for and mapping of the sites. Genetics 94:625–646Google Scholar
  5. Herman RK, Albertson DG, Brenner S (1976) Chromosome rearrangements in Caenorhabditis elegans. Genetics 83:91–105Google Scholar
  6. Herman RK, Kari CK, Hartman PS (1982) Dominant X-chromosome nondisjunction mutants of Caenorhabditis elegans. Genetics 102:379–400Google Scholar
  7. Herman RK, Madl JE, Kari CK (1979) Duplications in Caenorhabditis elegans. Genetics 92:419–435Google Scholar
  8. Hodgkin JA (1974) Genetic and anatomical aspects of the Caenorhabditis male. Ph.D. thesis, University of Cambridge, EnglandGoogle Scholar
  9. Hodgkin J (1980) More sex-determination mutants of Caenorhabditis elegans. Genetics 96:649–664Google Scholar
  10. Roberts PA (1976) The genetics of chromosome aberration. In: Ashburner M, Novitski E (eds) The genetics and biology of Drosophila, vol Ia. Academic Pres, New York, pp 68–184Google Scholar
  11. Rose AM, Baillie DL (1979a) The effect of temperature and parental age on recombination and nondisjunction in Caenorhabditis elegans. Genetics 92:409–418Google Scholar
  12. Rose AM, Baillie DL (1979b) A mutation in Caenorhabditis elegans that increases recombination frequency more than threefold. Nature 281:599–600Google Scholar
  13. Rose AM, Baillie DL (1980) Genetic organization of the region around unc-15(I), a gene affecting paramyosin in Caenorhabditis elegans. Genetics 96:639–648Google Scholar
  14. Rose AM, Baillie DL, Candido EPM, Beckenbach, Nelson D (1982) The linkage mapping of cloned restriction fragment length differences in Caenorhabditis elegans. Mol Gen Genet 188:286–291Google Scholar
  15. Rosenbluth RE, Baillie DL (1981) The genetic analysis of a reciprocal translocation, eT1(III,V), in Caenorhabditis elegans. Genetics 99:415–428Google Scholar
  16. Sandler I (1956) Studies in T(1;4) Bs in Drosophila melanogaster. M. Sc. thesis, University of MissouriGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • A. M. Rose
    • 1
  • D. L. Baillie
    • 2
  • J. Curran
    • 2
  1. 1.Dept. of Medical GeneticsUniversity of British ColumbiaVancouverCanada
  2. 2.Dept. of Biological SciencesSimon Fraser UniversityBurnabyCanada

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