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Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus in palm-oil medium

  • P. C. Lee
  • C. C. Ho
Research

Abstract

Palm and palm-kernel oils and their olein and stearin fractions were suitable as the main carbon sources for growth and production of clavulanic acid by Streptomyces clavuligerus. However, oleic and lauric acids were not utilized for growth. A spontaneous mutant, which was selected for higher cephamycin C production, also produced more clavulanic acid with these oils in the medium.

Key words

Cephamycin C clavulanic acid lipid mutation Streptomyces clavuligerus 

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Copyright information

© Rapid Science Publishers 1996

Authors and Affiliations

  • P. C. Lee
    • 1
  • C. C. Ho
    • 1
  1. 1.Department of Genetics and Cellular BiologyUniversity of MalayaKuala LumpurMalaysia

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