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World Journal of Urology

, Volume 1, Issue 2, pp 82–85 | Cite as

ABH-antigenicity of transitional cell carcinoma of the urinary bladder in patients subjected to topical chemoprophylaxis

  • Gerhard Jakse
  • Ferdinand Hofstädter
  • Udo Engelmann
  • Günther H. Jacobi
Article

Summary

Topical chemoprophylaxis with adriamycin was administered to 49 patients with UICC-stages pTA and PT1 (pathological stage 0 and A) of transitional cell carcinoma of the urinary bladder. Tumor specimens obtained prior to initiation of the instillation protocol were evaluated with regard to ABH-antigenicity. ABH-antigens were present in tumors of 19 patients and none of these developed muscle-infiltrating recurrences during or after intravesical chemoprophylaxis. The primary lesions of 30 patients were deleted of antigens; only 5 (16%) developed a progressive recurrence. Compared to a historical control group this is thought to be a true reduction of invasive tumor recurrences in ABH-negative tumors by adriamycin. We herein propose that ABH-antigenicity may serve as a valuable prescreening indicator for or against topical chemoprophylaxis.

Keywords

Public Health Carcinoma Cell Carcinoma Tumor Recurrence Urinary Bladder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Gerhard Jakse
    • 1
  • Ferdinand Hofstädter
    • 2
  • Udo Engelmann
    • 3
  • Günther H. Jacobi
    • 3
  1. 1.Urologische UniversitätsklinikInnsbruckAustria
  2. 2.Pathologisches Institut der UniversitätsklinikInnsbruckAustria
  3. 3.Urologische Klinik und Poliklinik im Klinikum der Johannes-Gutenberg-UniversitätMainzFederal Republic of Germany

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