, Volume 48, Issue 1, pp 19–25 | Cite as

High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects

  • R. E. Schmidt
  • U. Budde
  • C. Bröschen-Zywietz
  • G. Schäfer
  • C. Mueller-Eckhardt
Original Articles


This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. Different 7S-preparations such as β-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects.

Key words

High-dose gammaglobulin chronic idiopathic thrombocytopenic purpura platelet associated IgG 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • R. E. Schmidt
    • 1
    • 3
  • U. Budde
    • 2
    • 3
  • C. Bröschen-Zywietz
    • 1
    • 3
  • G. Schäfer
    • 2
    • 3
  • C. Mueller-Eckhardt
    • 2
    • 3
  1. 1.Medizinische Universitätsklinik BonnBonnFederal Republic of Germany
  2. 2.Institut für Experimentelle Hämatologie und BluttransfusionswesenBonnFederal Republic of Germany
  3. 3.Institut für Klinische Immunologie und Transfusionsmedizin, GießenGießenFederal Republic of Germany

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