Archives of Toxicology

, Volume 56, Issue 1, pp 66–67 | Cite as

Cytogenetic and genetic effects of subchronic treatments with organophosphorus insecticides

  • Noël Degraeve
  • Marie-Christine Chollet
  • Jean Moutschen
Short Communication

Abstract

Male mice (Q strain) received 5 days a week for 7 weeks drinking water containing dichlorvos (2 ppm), dimethoate (0.6 ppm), malathion (8 ppm), methylparathion (0.15 ppm), or trichlorfon (0.5 ppm). At the end of the treatment, no chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. Dominant lethal mutation assays were performed to investigate the pre- and postimplantation foetal lethality. Only negative results were obtained.

Key words

Subchronic treatments Genetic and cytogenetic effects Organophosphorus insecticides 

References

  1. Degraeve N, Moutschen J (1983) Genotoxicity of an organophosphorus insecticide, dimethoate, in the mouse. Mutat Res 119: 331–337Google Scholar
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Noël Degraeve
    • 1
  • Marie-Christine Chollet
    • 1
  • Jean Moutschen
    • 2
  1. 1.Laboratoire de Chimie MédicaleInstitut de PathologieSart Tilman par Liège 1Belgium
  2. 2.Laboratoire de GénétiqueUniversité de LiègeLiègeBelgium

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