Current Genetics

, Volume 28, Issue 2, pp 101–107

The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast

  • F. Randez-Gil
  • J. A. Prieto
  • P. Sanz
Original Paper

Abstract

2-deoxyglucose (2-DOG), a non-metabolize analogue of glucose, is taken up by yeast using the same transporter(s) as glucose and is phosphorylated by hexokinases producing 2-deoxyglucose-6-P. We found that in DOGR yeasts, 2-DOG was not able to trigger glucose repression, even at concentrations of 0.5%. This result suggests that the specific 2-DOG-6P phosphatase, the enzyme responsible for the DOGR phenotype, may be involved in inhibiting the process of catabolite repression mediated by 2-DOG

Key words

2-deoxyglucose 2-deoxyglucose-6P phosphatase Catabolite repression Saccharomyces cerevisiae 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • F. Randez-Gil
    • 1
  • J. A. Prieto
    • 1
  • P. Sanz
    • 1
  1. 1.Departamento BiotecnologíaInstituto Agroquímica y Tecnología de los Alimentos, (C.S.I.C.)ValenciaSpain

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