European Journal of Clinical Pharmacology

, Volume 40, Issue 1, pp 119–120 | Cite as

Fluvoxamine-tricyclic antidepressant interaction

An accidental finding
  • G. Bertschy
  • S. Vandel
  • B. Vandel
  • G. Allers
  • R. Volmat
Letters To The Editors

Key words

Fluvoxamine tricyclic antidepressants drug interaction 


  1. 1.
    Benfield P, Ward A (1986) Fluvoxamine a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32: 313–334Google Scholar
  2. 2.
    Claasen V (1983) Review of the animal pharmacology and pharmacokinetics of fluvoxamine. Br J Clin Pharmacol 15: 349S-355Google Scholar
  3. 3.
    Meador-Woodruff J, Akil M, Wisner-Carlson R, Grunhaus L (1988) Behavioral and cognitive toxicity related to elevated plasma tricyclic antidepressant levels. J Clin Psychopharmacol 8: 28–32Google Scholar
  4. 4.
    Rudorfer MW, Potter WZ (1987) Pharmacokinetics of antidepressants. In: Meltzer HY (ed) Psychopharmacology, the third generation of progress. Raven Press, New York, pp 1353–1363Google Scholar
  5. 5.
    Vandel B, Vandel S, Allers G, Bechtel P, Volmat R (1979) Interaction between amitriptyline and phenothiazines in man: effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response. Psychopharmacology 65: 187–190Google Scholar
  6. 6.
    Vandel B, Vandel S, Jounet JM, Allers G, Volmat R (1982) Relationship between the plasma concentration of clomipramine and desmethylclomipramine in depressive patients and the clinical response. Eur J Clin Pharmacol 22: 15–20Google Scholar
  7. 7.
    Vandel S, Bertschy G, Jounet JM, Allers G (1988) Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients. Ther Drug Monit 10: 386–389Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • G. Bertschy
    • 1
  • S. Vandel
    • 2
  • B. Vandel
    • 3
  • G. Allers
    • 1
  • R. Volmat
    • 1
  1. 1.Service de PsychiatrieFrance
  2. 2.Laboratoire de Pharmacologie Clinique CHUBesanconFrance
  3. 3.Laboratoire de Pharmacologie Clinique CHUPoitiersFrance

Personalised recommendations