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European Journal of Clinical Pharmacology

, Volume 41, Issue 6, pp 615–617 | Cite as

Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers

  • G. Bano
  • R. K. Raina
  • U. Zutshi
  • K. L. Bedi
  • R. K. Johri
  • S. C. Sharma
Short Communications

Summary

The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline.

In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.

Key words

Piperine Propranolol Theophylline pharmacokinetics drug interaction 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • G. Bano
    • 1
  • R. K. Raina
    • 1
  • U. Zutshi
    • 2
  • K. L. Bedi
    • 2
  • R. K. Johri
    • 2
  • S. C. Sharma
    • 2
  1. 1.Department of Pharmacology and TherapeuticsGovernment Medical CollegeJammu-TawiIndia
  2. 2.Regional Research LaboratoryJammu-TawiIndia

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