European Journal of Clinical Pharmacology

, Volume 41, Issue 4, pp 355–357 | Cite as

Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration

  • E. Rey
  • L. Delaunay
  • G. Pons
  • I. Murat
  • M. O. Richard
  • C. Saint-Maurice
  • G. Olive
Originals

Summary

Twelve children 1–5 y old were randomly assigned to receive midazolam 0.2 mg·kg−1 either by the intravenous (IV) or intranasal (IN) routes.

After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration.

The results are consistent with an estimated mean bioavailability of 55%.

Key words

Midazolam pharmacokinetics intranasal intravenous children bioavailability 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • E. Rey
    • 1
  • L. Delaunay
    • 2
  • G. Pons
    • 1
  • I. Murat
    • 2
  • M. O. Richard
    • 1
  • C. Saint-Maurice
    • 2
  • G. Olive
    • 1
  1. 1.Département de Pharmacologie Périnatale et PédiatriqueHôpital Saint-Vincent de PaulParisFrance
  2. 2.Département d'AnesthésiologieHôpital Saint-Vincent de PaulParisFrance

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