Molecular and Cellular Biochemistry

, Volume 24, Issue 2, pp 93–126 | Cite as

Gene activation during immune reaction

  • D. Jachertz
Review Articles
Received:

Summary

In cell-free systems the addition of antigen stimulates the synthesis of informational RNA (i-RNA) which exhibits the following properties: It codes for the entire antibody molecule, it codes for the synthesis of regulator protein which initiates transcription of i-RNA with the correspondent informational content from DNA, it is a template for an an i-RNA dependent RNA polymerase, it is a template for an i-RNA dependent reverse transcriptase. The i-RNA may exist in a state of latency in cells. The product of reverse transcription of i-RNA is i-DNA which can be used to transcribe further i-RNA of the same specificity. Similar to i-DNA is an extracellular DNA which codes also for antibody and from which i-RNA can be transcribed. The data presented are summarized in a scheme of the flow of information during immunological reactions.

It could be shown that there exist three different types of extrachromosomally synthesized molecules — i-RNA, i-DNA and extracellular DNA — which bear immunological specific information. These extrachromosomal states of information may be relevant for the generation of antibody diversity.

Keywords

Immune Reaction Reverse Transcriptase Reverse Transcription Gene Activation Regulator Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

i-RNA

informational RNA

i-DNA

informational DNA

AAP

antibody analogous product

BPoFlys

benzoyl-penicilloyl-formyl-l-lysine

HSV

Herpes simplex virus

HBs

Hepatitis virus B, surface antigen

HBsad

Hepatitis virus B, surface antigen, subtype ad

HBsay

hepatitis virus B, surface antigen, subtype ay

PPD

purified protein derivative of tuberculine

i-RNARk

i-RNA decoding for antibody against Rk

i-RNAR5

i-RNA coding for antibody against R5

R5

receptor particle for phage T5, derived from E. coli

Rk

receptor particle for phage kappa, derived from Serratia marcescens

SDS

sodium dodecyl sulfate

PBS

phosphate buffered saline

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Copyright information

© Dr. W. Junk b.v. Publishers 1979

Authors and Affiliations

  • D. Jachertz
    • 1
  1. 1.Institut für Hygiene und Medizinische Mikrobiologie der Universität BernBernSwitzerland

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