European Journal of Clinical Pharmacology

, Volume 38, Issue 1, pp 67–69

Effect of haemodialysis on the pharmacokinetics of cetirizine

  • W. M. Awni
  • J. Yeh
  • C. E. Halstenson
  • J. A. Opsahl
  • M. Chung
  • G. R. Matzke
Originals

DOI: 10.1007/BF00314806

Cite this article as:
Awni, W.M., Yeh, J., Halstenson, C.E. et al. Eur J Clin Pharmacol (1990) 38: 67. doi:10.1007/BF00314806

Summary

The pharmacokinetics of Cetirizine, a histamine H1-receptor antagonist, were investigated in five renal failure patients undergoing chronic haemodialysis therapy. The patients received one 10 mg cetirizine dihydrochloride capsule 3 h before haemodialysis.

Concentrations of cetirizine in serum and dialysate were determined by HPLC. The maximum serum cetirizine concentration and the time to reach that maximum were 285 μg·1−1 and 2.0 h, respectively. The terminal disposition half-life of cetirizine in these patients was 19.3 h.

The haemodialysis clearance of cetirizine was 14.0 ml · min−1. Although this is approximately 33% of the apparent total body clearance of cetirizine in subjects with normal renal function, the fraction of the dose removed by dialysis was only 9.4%. Thus, since haemodialysis does not produce a clinically significantly alteration in cetirizine elimination, no supplemental dose should be necessary after dialysis.

Key words

Cetirizine haemodialysis pharmacokinetics renal failure 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. M. Awni
    • 1
    • 2
    • 3
  • J. Yeh
    • 1
    • 2
    • 3
  • C. E. Halstenson
    • 1
    • 2
    • 3
  • J. A. Opsahl
    • 1
    • 2
    • 3
  • M. Chung
    • 1
    • 2
    • 3
  • G. R. Matzke
    • 1
    • 2
    • 3
  1. 1.The Drug Evaluation UnitHennepin County Medical CenterMinneapolisU.S.A.
  2. 2.College of Pharmacy and School of MedicineUniversity of MinnesotaMinneapolisU.S.A.
  3. 3.Pfizer PharmaceuticalsNew YorkU.S.A.

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