Journal of Neurology

, Volume 218, Issue 1, pp 23–33 | Cite as

Multiple sclerosis and malignant neoplasms in the central nervous system

A clinical anatomical report of three cases
  • F. W. Spaar
  • J. Wikström
Original Investigations

Summary

There is some evidence that the incidence of malignant neoplasms in the central nervous system of patients with multiple sclerosis (MS) is more infrequent than among the general population. The examination of 3 MS cases with different type of neoplasms in the central nervous system revealed mainly inactive demyelinated plaques. These plaques and the neoplastic lesions were dispersed diffusely and coincidentally all over the brain and spinal cord. The benign course of MS in all three cases is discussed in relation to the malignant diseases.

Key words

Multiple sclerosis Meningeosis carcinomatosa Bronchus carcinoma Malignant meningioma Demyelination 

Zusammenfassung

Das Vorkommen von Malignomen des ZNS bei der Multiplen Sklerose (MS) ist schon in der Klinik ein relativ seltenes Ereignis. Dafür sprechen auch die bisherigen Angaben der Literatur. Die Untersuchung von 3 MS-Fällen mit unterschiedlichen Neoplasmen des ZNS ergab allgemein inaktive Entmarkungsherde im Gehirn und Rückenmark. Die Herde und die Tumorproliferationen erwiesen sich in ihrer Lokalisation als unabhängig voneinander. Es wird erörtert, ob der gutartige Verlauf der MS in allen 3 Fällen i.S. einer Syntropie mit den malignen Erkrankungen zu deuten ist.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • F. W. Spaar
    • 1
  • J. Wikström
    • 1
  1. 1.Departments of Neuropathology and NeurologyUniversity of GöttingenGöttingenFederal Republic of Germany

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