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Journal of Neurology

, Volume 237, Issue 2, pp 113–116 | Cite as

Histopathological findings in the central and peripheral nervous systems in neuroborreliosis

A report of three cases
  • B. Meurers
  • W. Kohlhepp
  • R. Gold
  • E. Rohrbach
  • H. G. Mertens
Original Investigations

Summary

Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.

Key words

Neuroborreliosis Vasculitis Parenchymal infiltration Axonal degeneration Monoclonal antibodies 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • B. Meurers
    • 1
  • W. Kohlhepp
    • 1
  • R. Gold
    • 1
  • E. Rohrbach
    • 1
  • H. G. Mertens
    • 1
  1. 1.Neurologische Universitätsklinik und PoliklinikWürzburgFederal Republic of Germany

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