Journal of Neurology

, Volume 236, Issue 4, pp 238–242

Total, anti-viral, and anti-myelin IgG subclass reactivity in inflammatory diseases of the central nervous system

  • T. Mathiesen
  • H. van Holst
  • S. Fredrikson
  • G. Wirsén
  • B. Hederstedt
  • E. Norrby
  • V. -A. Sundqvist
  • B. Wahren
Short Communications

Summary

Total IgG subclass levels, anti-viral, anti-myelin basic protein (anti-MBP), and anti-ganglioside 1 (anti-GM1) IgG subclass levels were measured in 6 patients with herpes simplex virus encephalitis (HSVE), 16 with borreliosis, 8 with other bacterial infections, 12 with multiple sclerosis (MS), 13 with subacute sclerosing panencephalitis (SSPE), 5 with glioblastoma and 12 controls. Total IgG1 levels were elevated in cerebrospinal fluid (CSF) from all patient groups (but not in the controls), IgG2 in bacterial infections, IgG3 in HSVE and borreliosis and IgG4 in some SSPE patients. The anti-viral (anti-measles, varicella zoster virus and rubella) IgG antibodies in MS were restricted to IgG1, anti-measles IgG to IgG1 and sometimes IgG4 in SSPE, anti-borrelia IgG to IgG1, IgG2 and IgG3. In contrast to anti-viral antibodies, anti-MBP and GM1 antibodies belonged to IgG1, IgG3 or IgG4 in MS. The nature of the immunological activation appears to be reflected in the subclass patterns elicited in the central nervous system. Different IgG subclass patterns in infectious diseases and MS suggest a difference between antigen-specific and non-specific B-cell activation.

Key words

Intrathecal IgG synthesis IgG subclasses Multiple sclerosis Anti-viral antibodies 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • T. Mathiesen
    • 1
    • 2
    • 3
  • H. van Holst
    • 2
  • S. Fredrikson
    • 4
  • G. Wirsén
    • 1
  • B. Hederstedt
    • 5
  • E. Norrby
    • 3
  • V. -A. Sundqvist
    • 1
  • B. Wahren
    • 1
  1. 1.Department of VirologyNational Bacteriological LaboratoryStockholmSweden
  2. 2.Department of NeurosurgeryKarolinska InstituteStockholmSweden
  3. 3.Department of VirologyKarolinska InstituteStockholmSweden
  4. 4.Department of Neurology, Karolinska InstituteHuddinge HospitalHuddingeSweden
  5. 5.Department of BacteriologyNational Bateriological LaboratoryStockholmSweden

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