An immunohistochemical study of β-protein in Alzheimer-type dementia brains
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- Arai, H., Sagi, N., Noguchi, I. et al. J Neurol (1989) 236: 214. doi:10.1007/BF00314502
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An immunohistochemical study with a polyclonal anti-β-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of β-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.