Journal of Neurology

, Volume 236, Issue 4, pp 214–217

An immunohistochemical study of β-protein in Alzheimer-type dementia brains

  • H. Arai
  • N. Sagi
  • I. Noguchi
  • S. Haga
  • T. Ishii
  • Y. Makino
  • K. Kosaka
Original Investigations

DOI: 10.1007/BF00314502

Cite this article as:
Arai, H., Sagi, N., Noguchi, I. et al. J Neurol (1989) 236: 214. doi:10.1007/BF00314502

Summary

An immunohistochemical study with a polyclonal anti-β-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of β-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.

Key words

Alzheimer-type dementia Senile plaque Amyloid deposit β-Protein Immunohistochemistry 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. Arai
    • 1
  • N. Sagi
    • 1
  • I. Noguchi
    • 1
  • S. Haga
    • 2
  • T. Ishii
    • 2
  • Y. Makino
    • 4
  • K. Kosaka
    • 3
  1. 1.Department of PsychopharmacologyPsychiatric Research Institute of TokyoTokyoJapan
  2. 2.Department of Ultrastructure and HistochemistryPsychiatric Research Institute of TokyoTokyoJapan
  3. 3.Department of NeuropathologyPsychiatric Research Institute of TokyoTokyoJapan
  4. 4.Department of PsychiatryTokyo Metropolitan Matsuzawa HospitalTokyoJapan
  5. 5.Department of PsychiatryJuntendo University School of MedicineTokyoJapan

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