Journal of Neurology

, Volume 236, Issue 4, pp 199–202

Influence of nimodipine on cerebral blood flow in human cerebral ischaemia

  • C. Pozzilli
  • V. Di Piero
  • P. Pantano
  • M. Rasura
  • G. L. Lenzi
Original Investigations

DOI: 10.1007/BF00314499

Cite this article as:
Pozzilli, C., Di Piero, V., Pantano, P. et al. J Neurol (1989) 236: 199. doi:10.1007/BF00314499

Summary

Cerebral blood flow (CBF) was measured by xenon-133 inhalation and single photon emission computerized tomography (SPECT) in 7 patients with acute cerebral ischaemia prior to and 30 min after intravenous infusion of nimodipine (1 mg). Neurological examination, CT and CBF study were performed no later than 6 h after the onset of symptoms. Regional perfusion abnormalities were seen in all patients when the CT scan was still normal. Follow-up CT revealed low-density areas roughly corresponding to the core of the perfusion defect. Nimodipine infusion significantly decreased the mean arterial blood pressure (P<0.01), while PaCO2 and clinical symptoms remained unchanged. A significant CBF improvement (P<0.05) after nimodipine was seen in the border zone of the ischaemic infarct but not in the core of the lesion or in the unaffected contralateral hemisphere.

Key words

Cerebral blood flow Cerebral ischaemia Nimodipine 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • C. Pozzilli
    • 1
  • V. Di Piero
    • 1
  • P. Pantano
    • 1
  • M. Rasura
    • 1
  • G. L. Lenzi
    • 1
  1. 1.Department of Neurological ScienceUniversity of Rome “La Sapienza”RomeItaly

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