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Journal of Neurology

, Volume 236, Issue 5, pp 273–277 | Cite as

Diffuse “encephalitic” cerebral toxoplasmosis in AIDS

Report of four cases
  • Françoise Gray
  • Romain Gherardi
  • Elizabeth Wingate
  • Jeffrey Wingate
  • Gilles Fénelon
  • André Gaston
  • Alain Sobel
  • Jacques Poirier
Original Investigations

Summary

Four patients with AIDS presented with a rapidly fatal global neurologicl illness. CT did not show any focal lesion and gross post mortem examination of the brain was normal in three of the four cases. Microscopic examination revealed numerous widespread microglial nodules in the brain parenchyma, most containing central toxoplama cysts or free tachyzoites. Such diffuse, non-necrotic, “encephalitic” forms of cerebral toxoplasmosis appear unique to ADIS and, to our knowledge, have not been documented previously. They represent a treatable, often misdiagnosed cause of diffuse neurological involvement in AIDS patients.

Key words

Acquired immune deficiency syndrome (AIDS) Toxoplasmosis Encephalitis 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Françoise Gray
    • 1
    • 2
  • Romain Gherardi
    • 1
    • 2
  • Elizabeth Wingate
    • 1
  • Jeffrey Wingate
    • 1
  • Gilles Fénelon
    • 5
  • André Gaston
    • 3
  • Alain Sobel
    • 4
  • Jacques Poirier
    • 1
    • 2
  1. 1.Département de Pathologie (Neuropathologie)Hôptial Henri MondorCreteilFrance
  2. 2.Département Universitaire de Neurosciences Médicales, Faculté de Médecine de CréteilUniversité Paris-Val de MarneFrance
  3. 3.Service de NeuroradiologieHôpital Henri MondorCréteilFrance
  4. 4.Département d'Immunologie CliniqueHôpital Henri MondorCréteilFrance
  5. 5.Service de Clinique NeurologiqueHôpital TenonParisFrance

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