Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease
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A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
Key wordsAlzheimer's disease Immunolysis Cholinergic neurones Synaptosomes
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