Journal of Neurology

, Volume 234, Issue 2, pp 94–96

Depression and parkinson's disease: possible role of serotonergic mechanisms

  • V. S. Kostić
  • B. M. Djuričić
  • N. Čovičković-Šternić
  • L. Bumbaširević
  • M. Nikolić
  • B. B. Mršulja
Original Investigations


Depression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression.

Key words

Parkinson's disease Depression Human cerebrospinal fluid 5-Hydroxyindoleacetic acid 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • V. S. Kostić
    • 1
  • B. M. Djuričić
    • 2
  • N. Čovičković-Šternić
    • 1
  • L. Bumbaširević
    • 1
  • M. Nikolić
    • 1
  • B. B. Mršulja
    • 2
  1. 1.Department of NeurologySchool of MedicineBelgradeYugoslavia
  2. 2.Institute of BiochemistrySchool of MedicineBelgradeYugoslavia

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