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Journal of Neurology

, Volume 232, Issue 1, pp 13–14 | Cite as

Intrathecal thyrotropin-releasing hormone therapy of amyotrophic lateral sclerosis

  • T. Stober
  • K. Schimrigk
  • S. Dietzsch
  • T. Thielen
Original Investigations

Summary

Six patients with amyotrophic lateral sclerosis were given from 800 to 4000 μg of thyrotropin-releasing hormone (TRH) intrathecally for a period of 2–6 months. The progressive course of this disease, manifested by increasing atrophy, paralysis and disability score, was not altered. This supports the hypothesis that the decrease in TRH content in the anterior horn region is secondary to the cellular destruction. TRH appears to play no significant role in the pathogenesis of amyotrophic lateral sclerosis

Key words

Amyotrophic lateral sclerosis Cerebrospinal fluid Thyrotropin-releasing hormone 

References

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    Engel WK, Siddique T, Nicoloff JT (1983) Effect on weakness and spasticity in amyotrophic lateral sclerosis of thyrotropin-releasing hormone. Lancet II:73–75Google Scholar
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • T. Stober
    • 1
  • K. Schimrigk
    • 1
  • S. Dietzsch
    • 1
  • T. Thielen
    • 1
  1. 1.Department of NeurologyUniversity of SaarlandHomburg/SaarFederal Rebublic of Germany

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