Journal of Neurology

, Volume 234, Issue 1, pp 9–13 | Cite as

Regional cerebral blood flow in man at rest and during exercise

  • K. Herholz
  • W. Buskies
  • M. Rist
  • G. Pawlik
  • W. Hollmann
  • W. D. Heiss
Original Investigations


Regional cerebral blood flow (rCBF) of the left hemisphere was measured in 12 healthy young men at rest and during physical work on a bicycle ergometer in the supine position at work-load levels of 25 W or 100 W using the intravenous 133Xe method. Regional mean cerebral blood flow, regional gray-matter flow, and relative gray-matter weight was determined for six regions of interest. Arterial blood pressure, pulse frequency and expiratory CO2 concentration were recorded. Cerebral blood flow in all regions was significantly (P<0.001) higher during exercise than at rest. The increase in the 100 W group (24.7%) was significantly (P<0.05) greater than in the 25 W group (13.5%), but resting blood flow levels and alveolar CO2 concentrations were also different in both groups. Mean arterial blood pressure, pulse frequency and alveolar CO2 concentrations, but not arterial pCO2, were significantly higher during exercise and there was a faster washout of whole-body xenon. The CBF increase was interpreted as a combined effect of elevated systemic blood pressure and functionally activated brain metabolism. There was no evidence of impaired cerebral autoregulation.

Key words

Cerebral blood flow 133Xe Exercise Autoregulation 


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  1. 1.
    Bachofen H, Hobi HJ, Scherrer M (1973) Alveolar-arterial N2 gradients at rest and during exercise in healthy men of different ages. J Appl Physiol 34:137–142Google Scholar
  2. 2.
    Ekström-Jodal B, Häggendal E, Linder LE, Nilsson NJ (1977) The pressure-flow relations of the canine brain in acute mechanically induced arterial hypertension at different levels of cerebral blood flow. Acta Anaesthesiol Scand 2:232–239Google Scholar
  3. 3.
    Foreman DL, Sanders M, Bloor CM (1976) Total and regional cerebral blood flow during moderate and severe exercise in miniature swine. J Appl Physiol 40:191–195Google Scholar
  4. 4.
    Globus M, Melamed E, Keren A, Tzivoni D, Granot C, Lavy S, Stern S (1983) Effect of exercise on cerebral circulation. J Cereb Blood Flow Metab 3:287–290Google Scholar
  5. 5.
    Gross PM, Marcus ML, Heistad DD (1980) Regional distribution of cerebral blood flow during exercise in dogs. J Appl Physiol 48:213–217Google Scholar
  6. 6.
    Hedlund S, Nylin G, Regnström O (1962) The behaviour of the cerebral circulation during muscular exercise. Acta Physiol Scand 54:316–324Google Scholar
  7. 7.
    Heistad DD, Kontos HA (1983) Cerebral circulation. In: Handbook of Physiology, Sect 2, vol III. American Physiological Society, Bethesda, Maryland, pp 137–182Google Scholar
  8. 8.
    Herholz K (1985) Effect of recirculation and regional counting rate on reliability of noninvasive bicompartmental CBF measurements. Stroke 16:301–306Google Scholar
  9. 9.
    Hollmann W, Hettinger TH (1980) Sportmedizin — Arbeits- und Trainingsgrundlagen. Schattauer Verlag, Stuttgart New YorkGoogle Scholar
  10. 10.
    Ingvary, DH (1958) Cortical state of excitability and cortical circulation. In: Jasper HH, Proctor LD, Knighton RS, Noshay WC, Costello RT (eds) Reticular formation of the brain. Little, Brown and Co., Boston Toronto, pp 381–408Google Scholar
  11. 11.
    Ingvar DH, Philipson L (1977) Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance. Ann Neurol 2:230–237Google Scholar
  12. 12.
    Kleinerman J, Sancetta S (1955) Effect of mild steady state exercise on cerebral and general hemodynamics of normal untrained subjects. J Clin Invest 34:945–946Google Scholar
  13. 13.
    Kleinerman J, Sokoloff L (1953) Effect of exercise on cerebral blood flow and metabolism in man. Fed Proc 12:77Google Scholar
  14. 14.
    Lambertsen CJ, Owen SG, Wendel H, Stroud MW, Lurie AA, Lochner W, Clark GF (1959) Respiratory and cerebral circulatory control during exercise at.21 and 2.0 atmospheres inspired pO2. J Appl Physiol 14:966–982Google Scholar
  15. 15.
    Obrist WD, Thompson HK, Wang HS, Wilkinson WE (1975) Regional cerebral blood flow estimated by 133Xe inhalation. Stroke 6:245–256Google Scholar
  16. 16.
    Olesen J (1971) Contralateral focal increase of cerebral blood flow in man during arm work. Brain 94:635–646Google Scholar
  17. 17.
    Olesen J (1973) Quantitative evaluation of normal and pathologic cerebral blood flow regulation to perfusion pressure. Arch Neurol 28:143–150Google Scholar
  18. 18.
    Pannier JL, Leusen I (1977) Regional blood flow in response to exercise in conscious dogs. J Appl Physiol 36:255–265Google Scholar
  19. 19.
    Podreka I, Heiss WD, Brücke T (1981) Atraumatic CBF measurement with the scintillation camera. Comparison with intracarotid rCBF values. Stroke 12:47–53Google Scholar
  20. 20.
    Reis DJ, Iadecola C, McKenzie E, Mori M, Nakai M, Tucker LW (1982) Primary and metabolically coupled cerebrovascular dilation elicited by stimulation of two intrinsic systems of brain. In: Heistad DD, Markus ML (eds) Cerebral blood flow: effects of nerves and neurotransmitters. Elsevier North Holland. New York Oxford Shannon, pp 475–484Google Scholar
  21. 21.
    Roland PE, Skinhoj E, Lassen NA, Larsen B (1980) Different cortical areas in man in organization of voluntary movements in extrapersonal space. J Neurophysiol 43:137–150Google Scholar
  22. 22.
    Scheinberg P, Blackburn LI, Rich M, Saslaw M (1954) Effects of vigorous physical exercise on cerebral circulation and metabolism. Am J Med 16:549–554Google Scholar
  23. 23.
    Strandgaard S, Olesen J, Skinhoj E, Lassen NA (1973) Autoregulation of brain circulation in severe arterial hypertension. Br Med J 1:507–510Google Scholar
  24. 24.
    Whipp BJ, Wasserman K (1969) Alveolar-arterial gas tension differences during graded exercise. J Appl Physiol 27:361–365Google Scholar
  25. 25.
    Yamaguchi F, Meyer JS, Sakai F, Yamamoto M (1979) Normal human aging and cerebral vasoconstrictive responses to hypocapnia. J Neurol Sci 44:87–94Google Scholar
  26. 26.
    Zobl EG, Talmers FN, Christensen RC, Baer LJ (1965) Effect of exercise on the cerebral circulation and metabolism. J Appl Physiol 20:1289–1293Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • K. Herholz
    • 1
  • W. Buskies
    • 2
  • M. Rist
    • 2
  • G. Pawlik
    • 1
  • W. Hollmann
    • 2
  • W. D. Heiss
    • 1
  1. 1.Max-Planck-Institut für neurologische ForschungKöln 91 (Merheim)Federal Republik of Germany
  2. 2.Institut für Kreislaufforschung und Sportmedizin der Deutschen Sporthochschule KölnFederal Republik of Germany

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