Journal of Neurology

, Volume 230, Issue 3, pp 193–196 | Cite as

Plasma arginine vasopressin concentrations in epileptics under monotherapy

  • K. -H. Krause
  • W. Rascher
  • P. Berlit
Original Investigations

Summary

Plasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls. No significant difference was found between the groups, but some epileptics taking carbamazepine and primidone showed low values. Serum concentrations of carbamazepine did not correlate with the concentrations of plasma arginine vasopressin. In conclusion, there was no evidence of a stimulating effect of chronic carbamazepine medication or a special inhibiting effect of phenytoin on the release of vasopressin arginine from the posterior pituitary.

Key words

Arginine vasopressin Carbamazepine Anticonvulsants Epilepsy 

Zusammenfassung

Bei 112 unter Monotherapie mit Carbamazepin, Phenytoin, Primidon oder Valproat stehenden erwachsenen Anfallskranken sowie bei 19 gleichaltrigen Kontrollpersonen wurden radioimmunologisch die Vasopressin-Plasma-Konzentrationen bestimmt. Es wurden keine signifikanten Unterschiede zwischen den Gruppen gefunden. Einige der mit Carbamazepin und Primidon monotherapierten Epileptiker wiesen niedrige Vasopressin-Werte auf. Die Carbamazepin-Serumspiegel korrelierten nicht mit den Vasopressin-Konzentrationen. Somit ergab sich weder ein Hinweis auf eine vermehrte Vasopressin-Ausschüttung unter Langzeittherapie mit Carbamazepin noch eine besondere Hemmung der Ausschüttung durch Phenytoin.

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References

  1. 1.
    Ashton MG, Ball SG, Thomas TH, Lee MR (1977) Water intoxication associated with carbamazepine treatment. Br Med J 1:1134–1135Google Scholar
  2. 2.
    Fichman MP, Kleeman CR, Bethune JE (1970) Inhibition of antidiuretic hormone secretion by diphenylhydantoin. Arch Neurol 22:45–53Google Scholar
  3. 3.
    Heim M, Conte-Devolx B, Bonnefoy M, Bouyard P (1979) Mesure du taux de la 8-arginine vasopressine plasmatique par méthode de radioimmunologique chez la sujet normal, au cours d'und surcharge hydrique avant et pendent un traitement par carbamazépine. Pathol Biol (Paris) 27:95–98Google Scholar
  4. 4.
    Kimura T, Matsui K, Sato T, Yoshinaga K (1974) Mechanism of carbamazepine (Tegretol)-induced antidiuresis: Evidence for release of antidiuretic hormone and impaired excretion of a water load. J Clin Endocrinol Metab 38:356–362Google Scholar
  5. 5.
    Marsland RL (1982) Carbamazepine. Neurotoxicity. In: Woodbury DM, Penry JK, Pippenger CE (eds) Antiepileptic drugs, 2nd edn. Raven Press, New York, pp 521–531Google Scholar
  6. 6.
    Perucca E, Garratt A, Hebdige S, Richens A (1978) Water intoxication in epileptic patients receiving carbamazepine. J Neurol Neurosurg Psychiatry 41:713–718Google Scholar
  7. 7.
    Perucca E, Richens A (1980) Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction. J Neurol Neurosurg Psychiatry 43:540–545Google Scholar
  8. 8.
    Rascher W, Weidmann E, Gross F (1981) Vasopressin in the plasma of stroke-prone spontaneously hypertensive rats. Clin Sci 61:295–298Google Scholar
  9. 9.
    Smith NJ, Espir MLE, Baylis PH (1977) Raised plasma arginine vasopressin concentration in carbamazepine-induced water intoxication. Br Med J 2:804Google Scholar
  10. 10.
    Sordillo P, Sagransky DM, Mercado R, Micheln MF (1978) Carbamazepine-induced syndrome of inappropriate antidiuretic hormone secretion. Reversal of concomitant phenytoin therapy. Arch Intern Med 138:299–301Google Scholar
  11. 11.
    Stephens WP, Coe JY, Baylis PH (1978) Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine. Br Med J 1:1445–1447Google Scholar
  12. 12.
    Stephens WP, Espir MLE, Tattersall RB, Quinn NP, Gladwell SRF, Galbreith AW, Reynolds EH (1977) Water intoxication due to carbamazepine. Br Med J 1:754–755Google Scholar
  13. 13.
    Thomas TH, Ball SG, Wales JK, Lee MR (1979) Effect of carbamazepine on plasma and urine arginine-vasopressin. Clin Sci Mol Med 54:419–424Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • K. -H. Krause
    • 1
  • W. Rascher
    • 2
  • P. Berlit
    • 1
  1. 1.Neurological ClinicUniversity of HeidelbergHeidelbergGermany
  2. 2.Department of PharmacologyUniversity of HeidelbergHeidelbergGermany

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