Biological behavior of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide induced carcinoma of the transitional epithe-lium in the rat

  • H. Kiel
  • H. -D. Adolphs
  • J. Thiele
  • L. Steffens
Original Papers

Summary

30 female Wistar rats weighing between 70 and 90 g were fed for 8 months with 0,188% N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). After this period a papillary tumor of the urinary bladder was demonstrable in each animal. Histological examination always revealed a transitional cell carcinoma with prevailing medium tumor stages; no distant metastases were found. The grade of malignancy was classified as medium and high. No significant statistical relationship could be ascertained between tumor stage and grade or between grade and weight, but a correlation was established between tumor stage and weight. After 12 months, 36/60 kidneys were found to be normal, whereas in 20/60 dysplasias and in 2/60 transitional cell carcinomas of the renal pelvis were observed; secondary hydronephrosis due to bladder tumors occured 4 times. Other organ changes were not noticeable.

Key words

Chemical carcinogenesis Bladder tumor Grade Stage Renal changes 

Biologisches Verhalten von N[4-(5-Nitro-2-Furyl)-2-thiazolyl] Formamid —induzierten Karzinomen des Übergangsepithels der Ratte

Zusammenfassung

Bei 30 weiblichen Wistar Ratten mit einem Gewicht zwischen 70–90 g war nach 8 monatiger Fütterung mit 0,188 % N [4-(5-Nitro-2-Furyl)-2-Thiazolyl] Formamid (FANFT) bei allen Tieren ein papillärer Tumor der Harnblase nachweisbar. Histologisch handelte es sich dabei stets um ein Übergangszellkarzinom, wobei die mittleren Tumorstadien bevorzugt waren; Fernmetastasen lagen nicht vor. Die Klassifikation ergab einen mittleren und hohen Malignitätsgrad. Statistisch konnte keine signifikante Beziehung zwischen Tumorstadium und Grad sowie zwischen Grad und Tumorgewicht festgestellt werden. Dagegen bestand eine Korrelation zwischen Stadium und Tumorgewicht. Nach 12 Monaten zeigten 36/60 Nieren normale Befunde, während bei 20/60 Dysplasien und bei 2/60 Übergangszellkarzinome des Nierenbeckens beobachtet wurden. Eine sekundäre Harnstauungsniere als Folge des Blasentumors lag in 4 Fällen vor. Andere Organveränderungen wurden nicht festgestellt.

Schlüsselwörter

Chemische Karzinogenese Harnblasentumor Malignitätsgrad Stadium Nierenveränderungen 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • H. Kiel
    • 1
  • H. -D. Adolphs
    • 2
  • J. Thiele
    • 3
  • L. Steffens
    • 4
  1. 1.Department of Laboratory AnimalsChemie Grünenthal GmbH, Zweifaller StraßeStolbergFederal Republic of Germany
  2. 2.Department of UrologyUniversity of BonnBonnFederal Republic of Germany
  3. 3.Institute of Pathology, Medical SchoolHannoverFederal Republic of Germany
  4. 4.Department of UrologySt. Antonius HospitalEschweilerFederal Republic of Germany

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