Surgery Today

, Volume 26, Issue 3, pp 213–216

Cervical Castleman's disease associated with benign M-proteinemia: Report of a case

  • Makoto Komatsu
  • Takashi Ehara
  • Takai Kuroda
Case Reports


We report the unusual case of a 77-year-old man with cervical Castleman's disease associated with benign M-proteinemia. The patient was found to have an anterior cervical tumor during a follow-up examination after surgery for early gastric cancer, at which time blood biochemistry tests revealed M-proteinemia at the position of β-globulin with a high level of IgG and low levels of IgA and IgM. Serum protein immunoelectrophoresis revealed M-protein consisting of the IgG-k chain, and urine protein immunoelectrophoresis demonstrated Bence Jones protein consisting of the chain. No abnormalities were noted in bone marrow aspiration or bone scintigram. The results of imaging and fine-needle aspiration biopsy of the tumor led to a preoperative diagnosis of cervical malignant lymphoma with suspected M-proteinemia derived from this disease, and resection of the anterior cervical tumor with bilateral neck dissection was performed. Histopathological examination subsequently demonstrated four mixed-type tumors of Castleman's disease. The pathogenesis of Castleman's disease remains unknown; however, we speculate that the complication of benign M-proteinemia in this patient was not incidental, but caused by an underlying immunological abnormality of the B cells.

Key Words

Castleman's disease benign M-proteinemia immunological abnormality of the B cells 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Makoto Komatsu
    • 1
  • Takashi Ehara
    • 2
  • Takai Kuroda
    • 3
  1. 1.Department of SurgeryFujimi-kogen HospitalSuwaJapan
  2. 2.Department of PathologyShinshu University School of MedicineMatsumotoJapan
  3. 3.Department of SurgeryShinshu University School of MedicineMatsumotoJapan

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