Advertisement

Surgery Today

, Volume 23, Issue 2, pp 186–188 | Cite as

Patients with multiple primary gastric cancers tend to develop second primaries in organs other than the stomach

  • Nobuaki Kaibara
  • Michio Maeta
  • Masahide Ikeguchi
Short Communication

Abstract

The multiple occurrence of a single cancer tends to result in the increased vulnerability of some other organs to another malignancy. In the present study, we examined a total of 1,606 patients with gastric cancer to ascertain whether the frequency of second primaries in organs other than the stomach is higher in patients with multiple gastric cancers than in those with a single gastric cancer. Primary cancers of other organs were present in 87 (5.9%) of 1,474 patients with single gastric cancer and in 16 (12.1%) of 132 patients with multiple gastric cancers. The difference was statistically significant. The most frequent site of the occurrence of a second primary was the colo-rectum, followed by the urogenital organs, uterus, breast, and lung in descending order of frequency. We therefore assume that the occurrence of multiple cancers in the stomach is not merely a chance phenomenon but is related to both genetic predispostion and environmental factors.

Key Words

multiple gastric cancers single gastric cancer second primary malignancy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yamagiwa H, Yoshimura H, Matsusaki O, Ishihara A (1980) Pathological study of multiple gastric carcinomas. Acta Pathol Jpn 30:421–426Google Scholar
  2. 2.
    Kumagai K (1982) Clinicopathological study of multiple early gastric carcinomas and surrounding gastric mucosae (in Japanese with English Abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 83:285–296Google Scholar
  3. 3.
    Furukawa H, Iwanaga T, Ichikawa T, Hiratsuka M, Ohigashi H, Kameyama M, Sasaki Y, Ishikawa O, Kabuto T, Fukuda I, Imaoka S, Koyama H, Taniguchi K (1985) Multiple gastric cancers (in Japanese). Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 18:651–654Google Scholar
  4. 4.
    Kato I, Kito T, Nakazato H, Tominaga S (1986) Second malignancy in stomach cancer patients and its possible risk factors. Jpn J Clin Oncol 16:373–381Google Scholar
  5. 5.
    Anderson DE (1974) Genetic study of breast cancer: Identification of a high risk group. Cancer 34:1090–1097Google Scholar
  6. 6.
    Watanabe S, Komada T, Shimosato Y, Arimoto H, Suemasu K (1985) Second primary cancers in patients with gastrointestinal cancers. Jpn J Clin Oncol [Suppl I] 15:171–182Google Scholar
  7. 7.
    Yoshino K, Asanuma F, Hanatani Y, Otani Y, Kumai K, Ishibiki K (1985) Multiple primary cancers in the stomach and another organs: Frequency and the effect on prognosis. Jpn J Clin Oncol [Suppl I] 15:183–190Google Scholar
  8. 8.
    Schottenfeld D, Gantt RC, Wynder EL (1974) The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung: A prospective study. Prev Med 3:277–293Google Scholar
  9. 9.
    Vrabec DP (1979) Multiple primary malignancies of the upper aerodigestive system. Ann Otol Rhinol Laryngol 88:846–854Google Scholar
  10. 10.
    Seydel HG (1975) The risk of tumor induction in man following medical irradiation for malignant neoplasms. Cancer 35:1641–1645Google Scholar
  11. 11.
    Pedeisen-Bjergand J, Larsen SL (1982) Incidence of acute myelo-proliferative syndrome up to 10 years after treatment of Hodgkin's disease. N Engl J Med 307:965–971Google Scholar
  12. 12.
    Ichikawa T, Iwanaga T, Taniguchi K, Koyama H, Imaoka S, Fukuda I, Furukawa H, Kabuto T (1984) Double malignancies in the stomach and other organs: Analysis by the Person-years method (in Japanese with English Abstract). Nippon Gan Chiryo Gakkai Shi (J Jpn Soc Cancer Ther) 19:2157–2167Google Scholar
  13. 13.
    Bundred NJ, Whitfield BCS, Stanton E, Prescott RJ, Davies GC, Kingsnorth AN (1985) Gastric surgery and the risk of subsequent colorectal cancer. Br J Surg 72:618–619Google Scholar
  14. 14.
    Mizusawa K, Kaibara N, Yonekawa M, Ohta M, Sumi K, Kimura O, Nishidoi H, Koga S (1990) A prospective cohort study on the development of colorectal cancer after gastrectomy. Dis Colon Rect 33:298–301Google Scholar
  15. 15.
    Caygill CP, Hill MJ, Kirkham JS, Northfield TC (1987) Increased risk of cancer at multiple series after gastric surgery for peptic ulcer. Gut 28:924–928Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Nobuaki Kaibara
    • 1
  • Michio Maeta
    • 1
  • Masahide Ikeguchi
    • 1
  1. 1.First Department of Surgery, Faculty of MedicineTottori UniversityTottoriJapan

Personalised recommendations