Acta Neuropathologica

, Volume 83, Issue 5, pp 535–537 | Cite as

Affection of the hippocampal granule cells in pontosubicular neuron necrosis

  • A. Torvik
  • K. Skullerud
  • S. Norheim Andersen
  • J. Hurum
  • J. Mæhlen
Short Original Communication


The dentate fascia of the hippocampus was studied in 25 infants with pontosubicular necrosis and in 21 control cases without hypoxic cerebral lesions. Of the control cases 19 were completely normal and 2 showed one single necrotic cell in the granule cell layer. In contrast 15 of the cases with pontosubicular necrosis showed varying degrees of neuronal karyorrhexis in the dentate fascia. The severity of these changes largely parallelled those in the subiculum but there were exceptions to this rule. It is concluded that the dentate fascia is frequently involved in pontosubicular necrosis.

Key words

Perinatal hypoxic brain damage Pontosubicular necrosis Dentate fascia 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ahdab-Barmada M, Moossy J, Painter M (1980) Pontosubicular necrosis and hyperoxemia. Pediatrics 66:840–847Google Scholar
  2. 2.
    Ahdab-Barmada M, Moossy J, Nemeto EM, Lin MR (1986) Hyperoxia produces neuronal necrosis in the rat. J Neuropathol Exp Neurol 45:233–246Google Scholar
  3. 3.
    Auer RN, Wieloch T, Olsson Y, Siesjö BL (1984) The distribution of hypoglycemic brain damage. Acta Neuropathol (Berl) 64:177–191Google Scholar
  4. 4.
    Auer RN, Kalimo H, Olsson Y, Wieloch T (1985) The dentate gyrus in hypoglycemia: pathology implicating exitotoxinmediated neuron necrosis. Acta Neuropathol (Berl) 67:279–288Google Scholar
  5. 5.
    Friede RL (1972) Pontosubicular lesions in perinatal anoxia. Arch Pathol 94:343–354Google Scholar
  6. 6.
    Friede RL (1989) Pontosubicular neuron necrosis. In: Friede RL (ed) Development neuropathology. Springer Verlag, Berlin, pp 90–97Google Scholar
  7. 7.
    Grunnet ML (1979) Periventricular leucomalacia complex. Arch Pathol Lab Med 103:6–10Google Scholar
  8. 8.
    Larroche J-C (1984) Perinatal brain damage. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology, 4th edn. Edward Arnold, London, pp 451–489Google Scholar
  9. 9.
    Mæhlen J, Torvik A (1990) Necrosis of granule cells of hippocampus in adrenocortical failure. Acta Neuropathol 80:85–87Google Scholar
  10. 10.
    Ng T, Graham DJ, Adams JH, Ford I (1989) Changes in the hippocampus and cerebellum resulting from hypoxic insults: frequency and distribution. Acta Neuropathol 78:438–443Google Scholar
  11. 11.
    Rorke LB (1982) Pontosubicular necrosis. In: Rorke LB (ed) Pathology of perinatal brain injury. Raven Press, New York, pp 116–121Google Scholar
  12. 12.
    Skullerud K, Skjaeraasen J (1988) Clinicopathological study of germinal matrix hemorrhage, pontosubicular necrosis, and periventricular leucomalacia in stillborn. Child's Nerv Syst 4:88–91Google Scholar
  13. 13.
    Skullerud K, Westre B (1986) Frequency and prognostic significance of germinal matrix hemorrhage, periventricular leucomalacia, and pontosubicular necrosis in preterm neonates. Acta Neuropathol (Berl) 70:257–261Google Scholar
  14. 14.
    Sloviter RS, Valiguette G, Abrams GM, Rank LC, Sollas AL, Paul LA, Neubort S (1989) Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy. Science 243:535–538Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. Torvik
    • 1
  • K. Skullerud
    • 2
  • S. Norheim Andersen
    • 2
  • J. Hurum
    • 3
  • J. Mæhlen
    • 1
  1. 1.Division of Neuropathology, Department of PathologyUllevål University HospitalOsloNorway
  2. 2.Division of Neuropathology, Department of PathologyThe National HospitalOsloNorway
  3. 3.Department of PediatricThe National HospitalOsloNorway

Personalised recommendations