Acta Neuropathologica

, Volume 82, Issue 4, pp 280–285

Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein

  • T. Tokuda
  • S. Ikeda
  • N. Yanagisawa
  • Y. Ihara
  • G. G. Glenner
Regular Papers


A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid β-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and also β-protein immunoreactive senile plaques in the cortex. In the areas with many neurofibrillary tangles, neuropil threads with tau-immunoreactivity were also observed, and some of the senile plaque lesions were surrounded by abnormal neurites with tau-immunoreactivity. Moreover, three cases revealed β-protein-type cerebrovascular amyloid deposits on both leptomeningeal and cortical blood vessels. The present observations indicate that the cerebral pathology of dementia pugilistica is very similar to that of Alzheimer's disease and suggest that these two disorders share some common etiological and pathogenic mechanisms.

Key words

Dementia pugilistica Alzheimer's disease Amyloid angiopathy β-protein Tau protein 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • T. Tokuda
    • 1
  • S. Ikeda
    • 1
  • N. Yanagisawa
    • 1
  • Y. Ihara
    • 2
  • G. G. Glenner
    • 3
  1. 1.Department of Medicine (Neurology)Shinshu University School of MedicineMatsumotoJapan
  2. 2.Department of Neuropathology, Institute of Brain Research, Faculty of MedicineUniversity of TokyoTokyoJapan
  3. 3.Department of Pathology (0612)University of CaliforniaLa JollaUSA

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