Urological Research

, Volume 21, Issue 4, pp 289–291 | Cite as

Dose-dependent half-life of glycine

  • Robert G. Hahn
Original Articles


The serum concentration of glycine was measured at hourly intervals after administration of between 10 and 91 g glycine to 17 patients undergoing transurethral resection of the prostate and of between 15 and 22 g glycine to 18 volunteers by intravenous infusion. The apparent half-life of glycine varied 10-fold (range 26–245 min) and increased in direct proportion to the amount of glycine given. This result can be explained by assuming a marked intracellular accumulation of a surplus of glycine. The dose-dependent half-life means that patients who absorb large amounts of irrigating fluid are exposed to excessive blood levels of glycine for a prolonged period of time.

Key words

Blood Glycine Pharmacokinetics 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Robert G. Hahn
    • 1
  1. 1.Department of AnaesthesiologyHuddinge University HospitalHuddingeSweden

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