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Acta Neuropathologica

, Volume 80, Issue 4, pp 388–392 | Cite as

Incubation periods and histopathological changes in mice injected stereotaxically in different brain areas with the 87V scrapie strain

  • Y. S. Kim
  • R. I. Carp
  • S. Callahan
  • H. M. Wisniewski
Regular Papers

Summary

After stereotaxic injection into five different brain areas (cortex, caudate nucleus, substantia nigra, thalamus and cerebellum) of IM mice with the 87V scrapie strain, the cerebellum had the shortes incubation period. The vacuolation pattern was similar regardless of the area injected with extensive vacuolation in the thalamus, mesencephalon and hypothalamus. The pattern of amyloid plaques differed markedly depending on the area injected. In particular, no plaques were seen anywhere in the brain after injection into intact cerebellum, whereas injection into the four cerebral areas yielded plaques in the forebrain but not in the cerebellum. The incubation period after injection into bisected cerebella was much longer than after injection into intact cerebella. Mice injected on one side of bisected cerebellum had amyloid plaques in the forebrain but not in the cerebellum. There is a discussion of the finding that, although no plaques and virtually no vacuolation were seen in the cerebellum, the shortest incubation period occurred after injection into intact cerebellum.

Key words

Scrapie Stereotaxic injection Amyloid plaques Vacuolation Incubation period 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. S. Kim
    • 1
  • R. I. Carp
    • 1
  • S. Callahan
    • 1
  • H. M. Wisniewski
    • 1
  1. 1.New York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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