Theoretical and Applied Genetics

, Volume 70, Issue 5, pp 491–496

A FORTRAN program for the calculation and analysis of two-locus linkage disequilibrium coefficients

  • W. C. BlackIV
  • E. S. Krafsur

DOI: 10.1007/BF00305981

Cite this article as:
Black, W.C. & Krafsur, E.S. Theoret. Appl. Genetics (1985) 70: 491. doi:10.1007/BF00305981


A FORTRAN program was written that calculates composite linkage disequilibrium coefficients from genotypic data. Chi-square tests determine whether coefficients calculated for allele and locus pairs are significantly greater than zero. A subroutine is provided that partitions the variance in linkage disequilibrium into within- and between-subpopulation components. Output obtained from analysis of allozyme data collected from natural subpopulations of the house fly (Musca domestica L.) are included to illustrate features of the program.

Key words

FORTRAN Linkage disequilibrium Electrophoresis Breeding structure 

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • W. C. BlackIV
    • 1
  • E. S. Krafsur
    • 1
  1. 1.Department of EntomologyIowa State UniversityAmesUSA

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