Direct alkyl chain cleavage after C-hydroxylation of dialkylinitrosamines in rats. A new pathway of the oxidative biotransformation

  • L. Blattmann
Original Papers
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Summary

Comparative in vivo investigations on the biotransformation of di-n-butylnitrosamine (DBNA) and (2-hydroxybutyl)-n-butylnitrosamine (HBBNA) showed the known ω-oxidation. However, a new metabolic mechanism of direct oxidative alkyl chain cleavage in the vicinity of the hydroxy group of HBBNA could be demonstrated.

Keywords

Public Health Cancer Research Alkyl Chain Hydroxy Group Metabolic Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Direkte Alkylkettenspaltung nach C-Hydroxylierung von Dialkylnitrosaminen in Ratten. Ein neuer Weg der oxidativen Biotransformation

Zusammenfassung

Vergleichende Untersuchungen über die Biotransformation von di-n-butylnitrosamin (DBNA) und (2-hydroxybutyl)-n-butylnitrosamin (HBBNA) in vivo zeigten, daß außer der bekannten ω-Oxidation auch direkte oxidative Alkylkettenspaltung neben der OH-Gruppe von HBBNA stattfindet.

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • L. Blattmann
    • 1
  1. 1.Forschergruppe Präventivmedizin am Max-Planck-Institut für ImmunbiologieFreiburg i. Br.Federal Republic of Germany

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