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The effects of some carcinogenic nitroso compounds on the rat liver nucleolus

  • Kiyoshi Terao
Article

Summary

The hepatocyte nucleoli of rats undergo a variety of specific and nonspecific alterations after the administration of 8 nitroso compounds and 5 corresponding non-nitroso compounds. After the oral administration of dimethylnitrosamine and diethylnitrosamine, an unusual segregation of the nucleolus was encountered in the cells with karyorrhexis. Most characteristic of the segregation are the scattered ribosome-like granules at the outermost layer of the altered nucleolus. Frequently microspherules with halos 150 nm in diameter are found in all rats treated with nitroso compounds, which have been reported to be carcinogenic in the organs other than the liver. With the exception of butylurea and butylamine no such specific microspherules were found in the nucleoli after the administration of coresponding non-nitroso compounds.

Keywords

Public Health Cancer Research Oral Administration Nitroso Outermost Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Über die Wirkung einiger cancerogener Nitroso-Verbindungen auf die Nukleolen von Leberzellen der Ratte

Zusammenfassung

Die Nucleolen von Leberzellen der Ratte erleiden nach Gaben von 8 verschiedenen Nitrosoverbindungen und 5 entsprechenden Nicht-Nitrosoverbindungen eine Vielfalt von spezifischen und unspezifischen Veränderungen. Nach oraler Zufuhr von Dimethylnitrosamin und Diäthylnitrosamin wurde eine ungewöhnliche Segregation der Nukleolen in den Zellen mit Karyorrhexis beobachtet. Sehr kennzeichnend für diese Segregation sind verstreute Ribosomen-artige Granula in der äußersten Schicht der veränderten Nucleolen. Oft sind Mikrosphären mit Halos 150 nm in allen Ratten zu finden, die mit Nitrosoverbindungen behandelt wurden, welche als carcinogen für andere Organe als die Leber beschrieben wurden. Mit Ausnahme von Butylharnstoff und Butylamin wurden keine solche spezifischen Mikrosphären in den Nucleoli nach der Verabreichung der korrespondierenden Nicht-Nitrosoverbindungen beobachtet.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Kiyoshi Terao
    • 1
  1. 1.Research Institute for ChemobiodynamicsChiba UniversityChibaJapan

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