European Journal of Nuclear Medicine

, Volume 4, Issue 4, pp 271–275 | Cite as

The mechanism of the localization of 67Gallium citrate in experimental abscesses

  • Peter A. G. Hammersley
  • David M. Taylor


67Ga accumulation in turpentine-induced abscesses, from 5 h to 20 days old, in the rat has been investigated, and the results indicate that this is dependent on polymorphonuclear leukocyte (PMN) infiltration of the inflamed site. 67Ga concentration 24 h after injection correlates well with the activities of the lysosomal enzymes, aryl sulphatase and β-glucuronidase, P≪0.001, and with the DNA content of the tissue. There is no direct relationship with the rate of DNA synthesis.

The mechanism of lysosomal incorporation into PMNs is consistent with the factors involved in 67Ga uptake into tumours and normal tissues.


Polymorphonuclear Leukocyte Turpentine Lysosomal Enzyme Activity 67Ga Uptake 67Ga Accumulation 
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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Peter A. G. Hammersley
    • 1
  • David M. Taylor
    • 1
  1. 1.Radiopharmacology Department, Institute of Cancer ResearchRoyal Marsden HospitalSuttonU.K.

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