Rheumatology International

, Volume 11, Issue 3, pp 133–136

Quantitative clinical assessment of disease activity in systemic lupus erythematosus: progress report and research agenda

  • M. H. Liang
  • P. R. Fortin
  • D. A. Isenberg
  • L. Snaith
Clinical Aspects

DOI: 10.1007/BF00304502

Cite this article as:
Liang, M.H., Fortin, P.R., Isenberg, D.A. et al. Rheumatol Int (1991) 11: 133. doi:10.1007/BF00304502

Summary

No single test allows an adequate measure of disease activity in multisystem diseases such as systemic lupus erythematosus (SLE). In order to evaluate the spectrum of manifestations of disease activity in SLE, investigators have developed numerous ad hoc scales which have not been tested for their validity or reliability. Three instruments have been extensively studied: the British Isles Lupus Activity Group instrument (BILAG), the SLE Disease Activity Index (SLEDAI), and the Systemic Lupus Activity Measure (SLAM). All three have been demonstrated to have convergent and construct validity when compared to the clinician's judgement. The summation of the number of criteria of the American Rheumatism Association (ARA) SLE criteria has been shown to be an inadequate measure of disease activity. Standardized measures of disease activity for SLE should enhance our ability to compare results from different centers in finer distinctions than dead or alive.

Key words

SLE BILAG SLEDAI SLAM 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • M. H. Liang
    • 1
    • 2
  • P. R. Fortin
    • 1
    • 2
  • D. A. Isenberg
    • 3
  • L. Snaith
    • 3
  1. 1.Department of Rheumatology/Immunology, Harvard Medical School, Brigham and Womens HospitalRobert B. Brigham Multipurpose Arthritis CenterBostonUSA
  2. 2.Department of Medicine, Harvard Medical School, Brigham and Womens HospitalRobert B. Brigham Multipurpose Arthritis CenterBostonUSA
  3. 3.Bloomsbury Rheumatology UnitMiddlesex and University College HospitalLondonUK

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