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Archives of Toxicology

, Volume 45, Issue 1, pp 61–65 | Cite as

Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein

  • M. Younes
  • C. -P. Siegers
Article

Abstract

Dithiocarb and (+)-cyanidanol-3 prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 · 8 × 10−5 M for dithiocarb and 2 · 1 × 10−5 M for (+)-cyanidanol-3.

Key words

(+)-Cyanidanol-3 Diethyl ditbiocarbamate Dimethyl aminoethanol Dimethyl sulfoxide Hepatotoxicity Irreversible binding Rat liver microsomes 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • M. Younes
    • 1
  • C. -P. Siegers
    • 1
  1. 1.Institut für Toxikologie der Medizinischen Hochschule LübeckLübeckFederal Republic of Germany

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