Archives of Toxicology

, Volume 60, Issue 6, pp 467–469

The effect of a lipid suspension on amitriptyline disposition

  • N. A. Minton
  • A. G. Goode
  • J. A. Henry
Short Communication

DOI: 10.1007/BF00302392

Cite this article as:
Minton, N.A., Goode, A.G. & Henry, J.A. Arch Toxicol (1987) 60: 467. doi:10.1007/BF00302392

Abstract

A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.

Key words

Amitriptyline Lipid suspension 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • N. A. Minton
    • 1
  • A. G. Goode
    • 2
  • J. A. Henry
    • 1
  1. 1.Poisons UnitGuy's HospitalLondonUK
  2. 2.Guy's HospitalLondonUK

Personalised recommendations