Archives of Toxicology

, Volume 60, Issue 6, pp 467–469

The effect of a lipid suspension on amitriptyline disposition

  • N. A. Minton
  • A. G. Goode
  • J. A. Henry
Short Communication

Abstract

A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.

Key words

Amitriptyline Lipid suspension 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • N. A. Minton
    • 1
  • A. G. Goode
    • 2
  • J. A. Henry
    • 1
  1. 1.Poisons UnitGuy's HospitalLondonUK
  2. 2.Guy's HospitalLondonUK

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