Calcified Tissue International

, Volume 54, Issue 3, pp 195–197 | Cite as

Parathyroid hormone-related protein in healthy pregnant women

  • S. Bertelloni
  • G. I. Baroncelli
  • A. Pelletti
  • R. Battini
  • G. Saggese
Clinical Investigations


The object of this study was to determine whether increased circulating levels of parathyroid hormone-related protein (PTH-rp) may explain the increased parathyroid hormone (PTH) bioactivity in pregnancy. In 41 healthy pregnant women (age 19–41 years), PTH-rp and corrected calcium levels were measured and compared with those of nonpregnant control women (n=18, age 20–39 years). PTH-rp and corrected calcium levels were significantly higher in pregnant women (PTH-rp 21.9±7.9 pg/ml, P<0.001; corrected calcium 2.38±0.07 mmol/liter, P=0.001) than in nonpregnant women (PTH-rp 10.3±7.8 pg/ml; corrected calcium 2.30±0.10 mmol/liter). Our data indicate that circulating PTH-rp levels may significantly increase in pregnancy, suggesting a possible role of this peptide in the modification of calcium homeostasis in pregnant women.

Key words

Corrected calcium Parathyroid hormone-related protein Pregnancy 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pitkin RM (1985) Calcium metabolism in pregnancy and in perinatal period: a review. Am J Obstet Gynecol 151:99–109Google Scholar
  2. 2.
    Reitz RE, Daane TA, Woods JR, Weinstein RL (1977) Calcium, magnesium, phosphorus and parathyroid hormone relationships in pregnancy and newborn infants. Obstet Gynecol 50:701–705Google Scholar
  3. 3.
    Davis OK, Hawkins DS, Rubin LP, Posillico JT, Brown EM, Schiff I (1988) Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab 67:850–854Google Scholar
  4. 4.
    Frolich A, Rudnicki M, Fischer-Rasmussen W, Olofson K (1991) Serum concentrations of intact parathyroid hormone during late human pregnancy: a longitudinal study. Eur J Obstet Gynecol Reprod Biol 42:85–87Google Scholar
  5. 5.
    Allgrove J, Adami S, Manning RM, O'Riordan JLH, (1985) Cytochemical bioassay of parathyroid hormone in maternal and in cord blood. Arch Dis Child 60:110–115Google Scholar
  6. 6.
    Goltzman D, Stewart AF, Broadus AE (1981) Malignancy-associated hypercalcemia: evaluation with a cytochemical bioassay for parathyroid hormone. J Clin Endocrinol Metab 53: 899–904Google Scholar
  7. 7.
    Kao PC, Klee GG, Taylor RL, Heath H III (1990) Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions. Mayo Clin Proc 65:1399–1407Google Scholar
  8. 8.
    Ratcliffe WA, Hutchesson ACJ, Bundred NJ, Ratcliffe JG (1992) Role of assays for parathyroid hormone-related protein in investigation of hypercalcemia. Lancet 339:164–167Google Scholar
  9. 9.
    Burtis WJ (1992) Parathyroid hormone-related protein: structure, function, and measurement. Clin Chem 38:2171–2183Google Scholar
  10. 10.
    Mallette LE (1991) The parathyroid polyhormones: new concepts in the spectrum of peptide hormone action Endocrinol Rev 12:110–117Google Scholar
  11. 11.
    Juppner H, Abou-Samra AB, Uneno S, Gu WX, Potts JT Jr, Segre GV (1988) The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 263:8557–8560Google Scholar
  12. 12.
    Nissenson RA, Diep D, Strewler GJ (1988) Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem 263:12866–12871Google Scholar
  13. 13.
    Juppner H, Abou-Samra AB, Freeman M, et al. (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024–1026Google Scholar
  14. 14.
    Prechtl HFR (1980) The optimality concept. Early Hum Dev 4:211–215Google Scholar
  15. 15.
    Nelson N, Finnstrom O, Larsson L (1987) Neonatal reference values for ionized calcium, phosphate and magnesium: selection of reference population by optimality criteria. Scan J Clin Lab Invest 47:111–117Google Scholar
  16. 16.
    Bertelloni S, Baroncelli GI, Saggese G (1991) Parathyroid hormone-related peptide. Methodological evaluation of a new radioimmunoassay. Gior It Chim Clin 16:169–173Google Scholar
  17. 17.
    Payne RB, Little AJ, Williams RB, Milner JR (1973) Interpretations of serum calcium in patients with abnormal serum protein. Br Med J 4:643–646Google Scholar
  18. 18.
    Fisher JA (1986) The unique endocrine milieu of the fetus. J Clin Invest 78:603–611Google Scholar
  19. 19.
    Purdie DW, Aaron JE, Selby PL (1988) Bone histology and mineral homeostasis in human pregnancy. Br J Obstet Gynecol 95:849–854Google Scholar
  20. 20.
    Kumar R, Cohen WR, Silva P, et al. (1979) Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest 63:342–344Google Scholar
  21. 21.
    Payne RB, Little AJ, Evans RT (1990) Albumin-adjusted calcium concentration in serum increases during normal pregnancy. Clin Chem 36:142–144Google Scholar
  22. 22.
    Singer FR (1990) Parathyroid hormone-related protein. Mayo Clin Proc 65:1502–1505Google Scholar
  23. 23.
    Khosla S, Johansen KL, Ory SJ, O'Brien PC, Kao PC (1990) Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc 65:1408–1414Google Scholar
  24. 24.
    Gillette ME, Insogna KL, Lewis AM, Baran DT (1982) Influence of pregnancy on immunoreactive parathyroid hormone levels. Calcif Tissue Int 34:9–12Google Scholar
  25. 25.
    Abbas SK, Pickard DW, Illigworth D, et al. (1990) Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes. J. Endocrinol 124: 319–325Google Scholar
  26. 26.
    Ratcliffe WA, Thompson GE, Care AD, Peaker M (1992) Production of parathyroid hormone-related protein by mammary gland of the goat. J Endocrinol 133:87–93Google Scholar
  27. 27.
    Reid IR, Wattie DJ, Evans MC, Budayr AA (1992) Postpregnancy osteoporosis associated with hypercalcemia. Clin Endocrinol (Oxf) 37:298–303Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • S. Bertelloni
    • 1
  • G. I. Baroncelli
    • 1
  • A. Pelletti
    • 2
  • R. Battini
    • 1
  • G. Saggese
    • 1
  1. 1.Endocrine Unit, Chair of Preventive Pediatrics, Department of PediatricsUniversity of PisaPisaItaly
  2. 2.Division of Obstetrics and GynaecologyLucchesi's HospitalPietrasantaItaly

Personalised recommendations