Advertisement

Calcified Tissue International

, Volume 54, Issue 3, pp 195–197 | Cite as

Parathyroid hormone-related protein in healthy pregnant women

  • S. Bertelloni
  • G. I. Baroncelli
  • A. Pelletti
  • R. Battini
  • G. Saggese
Clinical Investigations

Abstract

The object of this study was to determine whether increased circulating levels of parathyroid hormone-related protein (PTH-rp) may explain the increased parathyroid hormone (PTH) bioactivity in pregnancy. In 41 healthy pregnant women (age 19–41 years), PTH-rp and corrected calcium levels were measured and compared with those of nonpregnant control women (n=18, age 20–39 years). PTH-rp and corrected calcium levels were significantly higher in pregnant women (PTH-rp 21.9±7.9 pg/ml, P<0.001; corrected calcium 2.38±0.07 mmol/liter, P=0.001) than in nonpregnant women (PTH-rp 10.3±7.8 pg/ml; corrected calcium 2.30±0.10 mmol/liter). Our data indicate that circulating PTH-rp levels may significantly increase in pregnancy, suggesting a possible role of this peptide in the modification of calcium homeostasis in pregnant women.

Key words

Corrected calcium Parathyroid hormone-related protein Pregnancy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pitkin RM (1985) Calcium metabolism in pregnancy and in perinatal period: a review. Am J Obstet Gynecol 151:99–109Google Scholar
  2. 2.
    Reitz RE, Daane TA, Woods JR, Weinstein RL (1977) Calcium, magnesium, phosphorus and parathyroid hormone relationships in pregnancy and newborn infants. Obstet Gynecol 50:701–705Google Scholar
  3. 3.
    Davis OK, Hawkins DS, Rubin LP, Posillico JT, Brown EM, Schiff I (1988) Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab 67:850–854Google Scholar
  4. 4.
    Frolich A, Rudnicki M, Fischer-Rasmussen W, Olofson K (1991) Serum concentrations of intact parathyroid hormone during late human pregnancy: a longitudinal study. Eur J Obstet Gynecol Reprod Biol 42:85–87Google Scholar
  5. 5.
    Allgrove J, Adami S, Manning RM, O'Riordan JLH, (1985) Cytochemical bioassay of parathyroid hormone in maternal and in cord blood. Arch Dis Child 60:110–115Google Scholar
  6. 6.
    Goltzman D, Stewart AF, Broadus AE (1981) Malignancy-associated hypercalcemia: evaluation with a cytochemical bioassay for parathyroid hormone. J Clin Endocrinol Metab 53: 899–904Google Scholar
  7. 7.
    Kao PC, Klee GG, Taylor RL, Heath H III (1990) Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions. Mayo Clin Proc 65:1399–1407Google Scholar
  8. 8.
    Ratcliffe WA, Hutchesson ACJ, Bundred NJ, Ratcliffe JG (1992) Role of assays for parathyroid hormone-related protein in investigation of hypercalcemia. Lancet 339:164–167Google Scholar
  9. 9.
    Burtis WJ (1992) Parathyroid hormone-related protein: structure, function, and measurement. Clin Chem 38:2171–2183Google Scholar
  10. 10.
    Mallette LE (1991) The parathyroid polyhormones: new concepts in the spectrum of peptide hormone action Endocrinol Rev 12:110–117Google Scholar
  11. 11.
    Juppner H, Abou-Samra AB, Uneno S, Gu WX, Potts JT Jr, Segre GV (1988) The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 263:8557–8560Google Scholar
  12. 12.
    Nissenson RA, Diep D, Strewler GJ (1988) Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem 263:12866–12871Google Scholar
  13. 13.
    Juppner H, Abou-Samra AB, Freeman M, et al. (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024–1026Google Scholar
  14. 14.
    Prechtl HFR (1980) The optimality concept. Early Hum Dev 4:211–215Google Scholar
  15. 15.
    Nelson N, Finnstrom O, Larsson L (1987) Neonatal reference values for ionized calcium, phosphate and magnesium: selection of reference population by optimality criteria. Scan J Clin Lab Invest 47:111–117Google Scholar
  16. 16.
    Bertelloni S, Baroncelli GI, Saggese G (1991) Parathyroid hormone-related peptide. Methodological evaluation of a new radioimmunoassay. Gior It Chim Clin 16:169–173Google Scholar
  17. 17.
    Payne RB, Little AJ, Williams RB, Milner JR (1973) Interpretations of serum calcium in patients with abnormal serum protein. Br Med J 4:643–646Google Scholar
  18. 18.
    Fisher JA (1986) The unique endocrine milieu of the fetus. J Clin Invest 78:603–611Google Scholar
  19. 19.
    Purdie DW, Aaron JE, Selby PL (1988) Bone histology and mineral homeostasis in human pregnancy. Br J Obstet Gynecol 95:849–854Google Scholar
  20. 20.
    Kumar R, Cohen WR, Silva P, et al. (1979) Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest 63:342–344Google Scholar
  21. 21.
    Payne RB, Little AJ, Evans RT (1990) Albumin-adjusted calcium concentration in serum increases during normal pregnancy. Clin Chem 36:142–144Google Scholar
  22. 22.
    Singer FR (1990) Parathyroid hormone-related protein. Mayo Clin Proc 65:1502–1505Google Scholar
  23. 23.
    Khosla S, Johansen KL, Ory SJ, O'Brien PC, Kao PC (1990) Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc 65:1408–1414Google Scholar
  24. 24.
    Gillette ME, Insogna KL, Lewis AM, Baran DT (1982) Influence of pregnancy on immunoreactive parathyroid hormone levels. Calcif Tissue Int 34:9–12Google Scholar
  25. 25.
    Abbas SK, Pickard DW, Illigworth D, et al. (1990) Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes. J. Endocrinol 124: 319–325Google Scholar
  26. 26.
    Ratcliffe WA, Thompson GE, Care AD, Peaker M (1992) Production of parathyroid hormone-related protein by mammary gland of the goat. J Endocrinol 133:87–93Google Scholar
  27. 27.
    Reid IR, Wattie DJ, Evans MC, Budayr AA (1992) Postpregnancy osteoporosis associated with hypercalcemia. Clin Endocrinol (Oxf) 37:298–303Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • S. Bertelloni
    • 1
  • G. I. Baroncelli
    • 1
  • A. Pelletti
    • 2
  • R. Battini
    • 1
  • G. Saggese
    • 1
  1. 1.Endocrine Unit, Chair of Preventive Pediatrics, Department of PediatricsUniversity of PisaPisaItaly
  2. 2.Division of Obstetrics and GynaecologyLucchesi's HospitalPietrasantaItaly

Personalised recommendations