Rheumatology International

, Volume 12, Issue 6, pp 235–238 | Cite as

Serological profile of rheumatoid arthritis in West Africa

  • A. O. Adebajo
  • P. J. Charles
  • B. L. Hazleman
  • R. N. Maini


Rheumatoid arthritis (RA) in West Africa is atypical in a number of respects. In order to investigate this we evaluated the serological profile of a series of West African patients diagnosed as having RA. We found the presence of a wide range of autoantibodies including antinuclear antibodies (ANA), anticardiolipin antibodies and antineutrophil cytoplasmic antibodies but the pattern of these autoantibodies was similar to that reported in other studies. Our serological studies support the hypothesis that these patients do have RA and the presence of these autoantibodies is of interest with regards to implications for diagnosis.

Key words

Rheumatoid arthritis West Africa Autoantibodies 


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  1. 1.
    Muller AS, Valkenburg HA, Greenwood BM (1972) Rheumatoid arthritis in three West African populations. East Afr Med J 49:75–83Google Scholar
  2. 2.
    Lawrence JS (1975) Rheumatism in populations. Heinemann, LondonGoogle Scholar
  3. 3.
    Adebajo AO, Davis P (1992) Rheumatology on the Dark Continent: not as dark as it was. J Rheumatol 19:195–197Google Scholar
  4. 4.
    Greenwood BM (1969) Polyarthritis in Western Nigeria. I. rheumatoid arthritis. Ann Rheum Dis 28:488–496Google Scholar
  5. 5.
    Adebajo AO, Reid DM (1991) The pattern of rheumatoid arthritis in West Africa and comparison with a cohort of British patients. Q J Med 80:633–640Google Scholar
  6. 6.
    Ropes MW, Bennett GA, Cobb S, Jacox R, Jessar RA (1959) Revision of diagnostic criteria in rheumatoid arthritis. Bull Rheum Dis 9:175–176Google Scholar
  7. 7.
    Chapman JR, Charles PJ, Venables PJ, Thompson PJ, Halsam PL, Maini RN, Turner-Warwick ME (1984) Definition and clinical relevance of antibodies to nuclear RNP and other nuclear antigens in patients with cryptogenic fibrosing alveolitis. Am Rev Respir Dis 130:439–443Google Scholar
  8. 8.
    Charles LA, Falk RJ, Jennette JC (1989) Reactivity of anti-neutrophil cytoplasmic autoantibodies with HL-60 cells. Clin Immunol Immunopathol 53:243–253Google Scholar
  9. 9.
    Adebajo AO, Charles P, Maini RN, Hazleman BL (1992) Anticardiolipin antibodies in association with chronic infections. Br J Rheumatol 31:45Google Scholar
  10. 10.
    Adebajo AO, Birrell F, Hazleman BL (1993) The pattern of rheumatic disorders seen amongst patients attending urban and rural clinics in West Africa. Clin Rheum (in press)Google Scholar
  11. 11.
    Holligan S, Birrell F, Adebajo A, Asuzu M, Thomson W, Ollier WER, Silman AJ (1991) Low prevalence of rheumatoid arthritis in a rural Nigerian population. Br J Rheumatol 30:1Google Scholar
  12. 12.
    Shaper AG, Kaplan MH, Moby NJ, McIntyre PA (1986) Malaria antibodies and autoantibodies to heart and other tissues in the immigrant and indigenous peoples of Uganda. Lancet 1:1342–1346.Google Scholar
  13. 13.
    Notman DD, Kurata N, Tan EM (1975) Profiles of antinuclear antibodies in systemic rheumatic disease. Ann Intern Med 83:464–469Google Scholar
  14. 14.
    Davis P, Stein M, Ley H, Johnston C (1989) Serological profiles in the connective tissue diseases in Zimbabwean patients. Ann Rheum Dis 48:73–76Google Scholar
  15. 15.
    Wilson MR, Tan EM (1986) Antinuclear antibodies and the LE cell phenomena. In: Cohen AS, Bennett JC (eds) Rheumatology and immunology. Grune and Stratton, OrlandoGoogle Scholar
  16. 16.
    Holborow EJ (1986) Autoantibodies in the rheumatic diseases. In: Scott JT (ed) Copeman's textbook of the rheumatic diseases. Churchill Livingstone, EdinburghGoogle Scholar
  17. 17.
    Smeenk R, Lelij G van der, Aarden L (1982) Avidity of antibodies to ds DNA: comparison of IFT onCrithidia lucillae, Farr assay, and PEG assay. J Immunol 128:73–78Google Scholar
  18. 18.
    Greenwood BM, Whittle HC (1981) Immunology of medicine in the tropics. Edward Arnold, LondonGoogle Scholar
  19. 19.
    Cohen Tevaert JW, Goldschmeding R, Elema JD, Limburg PC, Giessen van der M, Huiteman MG, Koolen MI, Hene' RJ, The TH, Hem GK van der, Borne AEG van der, Kallenberg CGM (1990) Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum 33:1264–1272Google Scholar
  20. 20.
    Lassoued S, Sixou L, Oksman F, Pages M, Fournie A (1991) ANCA and antibodies to MPO in RA. Arthritis Rheum 34:1069–1070Google Scholar
  21. 21.
    Savage JA, Gallicchio MC, Stockman A, Cunningham TJ, Rowley MJ, Georgiou T, Davies D (1991) Anti-neutrophil cytoplasm antibodies in rheumatoid arthritis. Clin Exp Immunol 86:92–98Google Scholar
  22. 22.
    Panayi GS (1982) Viewpoint-does rheumatoid arthritis have a clinicopathological spectrum similar to that of leprosy? Ann Rheum Dis 42:102–103Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. O. Adebajo
    • 1
  • P. J. Charles
    • 2
  • B. L. Hazleman
    • 1
  • R. N. Maini
    • 2
  1. 1.Rheumatology Research UnitAddenbrooke's HospitalCambridgeUK
  2. 2.Department of RheumatologyCharing Cross HospitalLondonUK

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