Rheumatology International

, Volume 12, Issue 2, pp 43–45

The cilical effects of electrostimulation on salivary function of Sjögren's syndrome patients

A placebo controlled study
  • N. Talal
  • J. H. Quinn
  • T. E. Daniels
Originals

Summary

A multi-center double-blind study of an electro-stimulator device1 was conducted to evaluate its ability to increase the production of saliva and reduce clinical symptomatology. A total of 77 Sjögren's syndrome patients at three centers were assigned to active devices (n=40) or to placebo devices (n=37). There were 2 male and 32 female patients assigned to active devices, and 1 male and 36 female patients assigned to placebo devices. The age range with the greatest number of patients was 60–69 years making up more than 31% of the study population. The selection criteria required the patients to have no greater than 0.2 g/min of whole salivary production (approximately 19% of normal salivary production). At the start of the study, the patients assigned the active device had a mean salivary production of 0.06 ml per min (6% of normal) and patients assigned placebo devices had a mean salivary production of 0.07 ml per min (7% of normal). There were three scheduled visits, 2 weeks apart, over a treatment period of 4 weeks. At all visits, the patients using active devices showed a statistically greater (P=0.005 to 0.02) increase in the production of saliva than placebo patients. The study also evaluated the reduction of patients symptoms associated with xerostomia. Patients showed significant improvement in (1) difficulty in swallowing and (2) burning tongue (P=0.008). Some patients on their initial visit had no response to the active device and did not show a significant response at subsequent visits. These results demonstrated that electrostimulation was effective in stimulating increased production of saliva and in reducing the symptoms of xerostomia in patients with xerostomia secondary to Sjögen's syndrome.

Footnotes
  1. 1.

    Trade name: Salitron System manufactured by Biosonics, Inc., Ft. Washington, Pa., USA

Key words

Sjögren's syndrome Xerostomia Salitron System Electrostimulation 

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References

  1. 1.
    Talal N, Moutsopoulos HM, Kassan SS (eds) (1987) Sjögren's syndrome, clinical and immunological aspects, pp 193–202Google Scholar
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    Fox PC, Ven PF van der, Sonies BC, Weiffenbach JM, Baum BH (1985) “Xerostomia: evaluation of a symptom with increasing significance”. JADA 110:519–525Google Scholar
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    Jenkins GN (1978) Physiology and biochemistry of the mouth, 4th edn, chap 9: Saliva. Blackwell, Oxford, pp 284–359Google Scholar
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    Snedecor GW (1957) Statistical methods, 5th edn. The Iowa State College Press, Ames, Iowa, pp 382–384Google Scholar
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    Weiss WW, Brenman HS, Katz P (1986) Use of an electronic stimulator for the treatment of dry mouth. J Oral Maxillofac Surg 44:845–851Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • N. Talal
    • 1
  • J. H. Quinn
    • 2
  • T. E. Daniels
    • 3
  1. 1.The University of Texas Health Science CenterSan AntonioUSA
  2. 2.Luoisiana State University Medical CenterNew OrleansUSA
  3. 3.University of CaliforniaSan FranciscoUSA

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