Rheumatology International

, Volume 14, Issue 2, pp 71–75 | Cite as

How could infectious agents hide in synovial cells? Possible mechanisms of persistent viral infection in a model for the etiopathogenesis of chronic arthritis

  • H. -I. Huppertz
Original Article
Received:
Accepted:

Abstract

It has been hypothesized that a persistent intraarticular viral infection might play an important part in the pathogenesis of chronic arthritis. However, it remains unclear how such an infection could survive in synovial cells that express large amounts of HLA-DR and inter-cellular adhesion molecule-1 (ICAM-1) by which they communicate with immunocompetent cells. In an in vitro model of persistent mumps virus infection of synovial cells, results suggested that, in contrast to mock-infected cells, cells containing viral antigen did not express HLA-DR in response to interferon-gamma and that they did not up-regulate ICAM-1 expression under these conditions. Previously it has been shown that infected synovial cells do not express viral surface antigens. By these mechanisms, infected cells, interspersed among a large majority of uninfected cells, might evade recognition and eradication by the the immune system. Lack of neoantigen expression on infected cells might be an important viral strategy to maintain a persistent infection and to initiate and perpetuate joint inflammation.

Key words

Chronic arthritis Pathogenesis Viral persistence Mumps virus HLA-DR ICAM-1 
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References

  1. 1.
    Maksymowych WP, Glass DN (1988) Population genetics and molecular biology of the childhood chronic arthropathies. Baillieres Clin Rheumatol 2:649–671Google Scholar
  2. 2.
    Harris ED (1990) Rheumatoid arthritis, pathophysiology and implications for therapy. N Engl J Med 322:1277–1289Google Scholar
  3. 3.
    Sewell KL, Trentham DE (1993) Pathogenesis of rheumatoid arthritis. Lancet 341:283–286Google Scholar
  4. 4.
    Chantler JK, Tingle AJ, Petty RE (1985) Persistent rubella virus infection associated with chronic arthritis in children. N Engl J Med 313:1117–1123Google Scholar
  5. 5.
    Huppertz HI, Miki NP, Chantler JK (1991) Susceptability of normal human joint tissue to viruses. J Rheumatol 18:699–704Google Scholar
  6. 6.
    Huppertz HI, Chantler JK (1991) Restricted mumps virus infection of cells derived from normal human joint tissue. J Gen Virol 72:339–347Google Scholar
  7. 7.
    Gordon SC, Lauter CB (1984) Mumps arthritis: a review of the literature. Rev Infect Dis 6:338–344Google Scholar
  8. 8.
    Oldstone MB (1989) Viral persistence. Cell 56:517–520Google Scholar
  9. 9.
    Burmester GR, Dimitriu-Bona A, Waters SJ, Winchester RJ (1983) Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scand J Immunol 17:69–82Google Scholar
  10. 10.
    Haas JP, Andreas A, Rutkowski B, Brunner H, Keller E, Hoza J, Havelka S, Sierp G, Albert ED (1991) A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis. Rheumatol Int 11:191–197Google Scholar
  11. 11.
    Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF (1989) Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum 32:22–30Google Scholar
  12. 12.
    Chin JE, Winterrowd GE, Krzesicki RF, Sanders ME (1990) Role of cytokines in inflammatory synovitis. Arthritis Rheum 22:1776–1786Google Scholar
  13. 13.
    Haynes BF, Grover BJ, Whichard LP, Hale LP, Nunley JA, McCollum DE, Singer KH (1988) Synovial microenvironment-T cell interactions: human T cells bind to fibroblast-like synovial cells in vitro. Arthritis Rheum 31:947–955Google Scholar
  14. 14.
    Firestein GS, Zvaifler NJ (1987) Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. Arthritis Rheum 30:864–871Google Scholar
  15. 15.
    Parkkonen P, Hyoty H, Koskinen L, Leinikki P (1992) Mumps virus infects beta cells in human fetal island cell cultures upregulating the expression of HLA class I molecules. Diabetologia 35:63–69Google Scholar
  16. 16.
    Panayi GS (1992) The immunopathogenesis of rheumatoid arthritis. Clin Exp Rheumatol 10:305–307Google Scholar
  17. 17.
    Firestein GS, Zvaifler NJ (1990) How important are T-cells in chronic rheumatoid synovitis? Arthritis Rheum 33:768–773Google Scholar
  18. 18.
    Remmers EF, Sano H, Lafyatis R, Case JP, Kumkumian GK, Hla R, Maciag T, Wilder RL (1991) Production of platelet derived growth factor B chain mRNA and immunoreactive PDGF-B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. J Rheumatol 18:7–13Google Scholar
  19. 19.
    Shiozawa S, Tokuhisa T (1992) Contribution of synovial mesenchymal cells to the pathogenesis of rheumatoid arthritis. Semin Arthritis Rheum 21:267–273Google Scholar
  20. 20.
    Steere AC, Duray PH, Butcher EC (1988) Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Arthritis Rheum 31:487–495Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. -I. Huppertz
    • 1
  1. 1.Children's University HospitalWürzburgGermary

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